Evidence map›Paper›PMID 36998647›Full record

ArticleNanoscale advances2023

Sustained release of tumor cell lysate and CpG from an injectable, cytotoxic hydrogel for melanoma immunotherapy.

Kui Yang, Yuhan Zhou, Biwang Huang, Guifang Zhao, Yuan Geng, Chao Wan, Fagang Jiang, Honglin Jin, Chengzhi Ye, Jing Chen

Open access · goldAbstract read
In one paragraph

Article in Nanoscale advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Designing lysate-based hydrogels for on-demand therapy.Journal of pharmaceutical analysis · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Therapeutic Bioactivity Exerted by theMolecules (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Kui YangCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China chenjingwh@hust.edu.cn.
Yuhan ZhouCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China chenjingwh@hust.edu.cn.ORCID https://orcid.org/0000-0003-0206-9290
Biwang HuangOrthopaedic Department, General Hospital of Central Theater Command of PLA Wuhan China.
Guifang ZhaoCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China chenjingwh@hust.edu.cn.
Yuan GengCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University Wuhan China.
Chao WanCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China chenjingwh@hust.edu.cn.
Fagang JiangDepartment of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Honglin JinCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China chenjingwh@hust.edu.cn.
Chengzhi YeDepartment of Pediatrics, Renmin Hospital of Wuhan University Wuhan China ycz15391569970@163.com.
Jing ChenCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China chenjingwh@hust.edu.cn.
Union Hospital · CNHuazhong Agricultural University · CNWuhan General Hospital of Guangzhou · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many basic research studies have shown the potential of autologous cancer vaccines in the treatment of melanoma. However, some clinical trials showed that simplex whole tumor cell vaccines can only elicit weak CD8

Identifiers

PMID36998647
PMCPMC10044724
OpenAlexW4324278900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.