Evidence map›Paper›PMID 36998620›Full record

ArticleOncoimmunology2023

Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production.

Oleg Kruglov, Kavita Vats, Vishal Soman, Vladimir A Tyurin, Yulia Y Tyurina, Jiefei Wang, Li'an Williams, Jiying Zhang, Cara Donahue Carey, Erik Jaklitsch and 4 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Neuro-immune cross-talk in cancer.Nature reviews. Cancer · 2025
    Review
  11. Roles of Peripheral Nerves in Tumor Initiation and Progression.International journal of molecular sciences · 2025
    Review
  12. Article
  13. TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Article
  14. Review
  15. Schwann cells in regeneration and cancer.Frontiers in pharmacology · 2025
    Review
  16. Review
  17. Lipoxygenases at the Intersection of Infection and Carcinogenesis.International journal of molecular sciences · 2024
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Oleg KruglovDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kavita VatsDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Vishal SomanDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Vladimir A TyurinCenter for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
Yulia Y TyurinaCenter for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
Jiefei WangDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Li'an WilliamsDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jiying ZhangDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Cara Donahue CareyDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Erik JaklitschSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Uma R ChandranDepartment of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Hülya BayirCenter for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.
Valerian E KaganDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yuri L BunimovichDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
Lipids and Myeloid Cell Function in CancerR01CA165065 · NCI · WISTAR INSTITUTE · PI KAGAN, VALERIAN E, MONTANER, LUIS J · 2012 to 2022
$3.8M
The Role of Schwann Cells in the Progression of MelanomaR01CA266529 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuri Bunimovich · 2023 to 2026
$1.8M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA165065NCI NIH HHS R01 CA266529NHLBI NIH HHS P01 HL114453
6 · The paper itself

Abstract

Peripheral glia, specifically the Schwann cells (SCs), have been implicated in the formation of the tumor microenvironment (TME) and in cancer progression. However,

Indexed as

Arachidonate 15-LipoxygenaseMelanomaAnimalsCyclooxygenase 2EicosanoidsMiceSchwann CellsT-LymphocytesTumor MicroenvironmentArachidonate 15-LipoxygenaseCyclooxygenase 2EicosanoidsCancermelanomaneuroimmunologySchwann celltumor microenvironment

Identifiers

PMID36998620
PMCPMC10044150
OpenAlexW4360951773

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.