Evidence map›Paper›PMID 36998614›Full record

ArticleFrontiers in pharmacology2023

PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia.

Julia Macente, Nina Nauwelaerts, Francesca M Russo, Jan Deprest, Karel Allegaert, Bart Lammens, Rodolfo Hernandes Bonan, Jessica M Turner, Sailesh Kumar, Andrea Diniz and 2 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Julia MacenteDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Nina NauwelaertsDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Francesca M RussoGynecology and Obstetrics, UZ Leuven, Leuven, Belgium.
Jan DeprestGynecology and Obstetrics, UZ Leuven, Leuven, Belgium.
Karel AllegaertDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Bart LammensBioNotus GCV, Niel, Belgium.
Rodolfo Hernandes BonanBioNotus GCV, Niel, Belgium.
Jessica M TurnerMater Research Institute, University of Queensland, Brisbane, QLD, Australia.
Sailesh KumarMater Research Institute, University of Queensland, Brisbane, QLD, Australia.
Andrea DinizPharmacokinetics and Biopharmaceutical Laboratory (PKBio), Department of Pharmacy, State University of Maringa, Maringa, Brazil.
Frederico S MartinsPharmacokinetics and Biopharmaceutical Laboratory (PKBio), Department of Pharmacy, State University of Maringa, Maringa, Brazil.
Pieter AnnaertDepartment of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
KU Leuven · BEUniversidade Estadual de Maringá · BRUniversitair Ziekenhuis Leuven · BEErasmus MC · NLMater Research · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sildenafil is a potent vasodilator and phosphodiesterase type five inhibitor, commercially known as Revatio

Indexed as

congenital diaphragmatic herniaMIDDmodel informed drug developmentPBPKphysiologically-based pharmacokinetic modellingpregnant womenrevatiosildenafil

Identifiers

PMID36998614
PMCPMC10043195
OpenAlexW4324145297

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read17
measurements read58
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.