Evidence map›Paper›PMID 36998602›Full record

ArticleInternational journal of nanomedicine2023

"Shell-Core" Bilayer Nanoparticle as Chemotherapeutic Drug Co-Delivery Platforms Render Synchronized Microenvironment Respond and Enhanced Antitumor Effects.

Jia Zeng, Peng Sun, Xinning Fang, Yicheng Jiang, Zhenghong Wu, Xiaole Qi

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jia ZengKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, People's Republic of China.
Peng SunKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, People's Republic of China.
Xinning FangKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, People's Republic of China.
Yicheng JiangKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, People's Republic of China.
Zhenghong WuKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, People's Republic of China.
Xiaole QiKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, People's Republic of China.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Synergistic chemotherapy has been proved as an effective antitumor means in clinical practice. However, most co-administration treatment often lacks simultaneous control over the release of different chemotherapeutic agents. Materials and Methods: Results: These BNs had a spherical structure with the particle size of 299 ± 15.17 nm, while the synchronized release behaviour of those two drugs was proved in the medium with the pH value of 5.5 and 20 mM GSH. The co-delivery of DOX and CUR reduced the IC Conclusion: The designed bilayer nanoparticle could be considered as potential chemotherapeutic co-delivery platform for efficient synchronized microenvironment respond and drug release. Furthermore, the simultaneous and synergistic drug release guaranteed the enhanced antitumor effects during the co-administration treatment.

Indexed as

CurcuminNanoparticlesNeoplasmsAnimalsDoxorubicinDrug CarriersDrug Delivery SystemsDrug LiberationHydrogen-Ion ConcentrationMiceTumor MicroenvironmentCurcuminDoxorubicinDrug Carrierscombination chemotherapypH- and GSH-responsivetumor microenvironmenttumor targeting

Identifiers

PMID36998602
PMCPMC10046155
OpenAlexW4360874956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.