Evidence map›Paper›PMID 36998574›Full record

ReviewFrontiers in allergy2023

A short history from Karelia study to biodiversity and public health interventions.

Tari Haahtela, Harri Alenius, Petri Auvinen, Nanna Fyhrquist, Leena von Hertzen, Pekka Jousilahti, Piia Karisola, Tiina Laatikainen, Jenni Lehtimäki, Laura Paalanen and 9 more

Open access · goldFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Allergy prevention-a new public health perspective.European journal of public health · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Prevention of Atopic Dermatitis: What Are We Missing?Allergy, asthma & immunology research · 2025
    Review
  7. Article
  8. Observational
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 4 countries.

Tari HaahtelaSkin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
Harri AleniusHuman Microbiome Research (HUMI), Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Petri AuvinenDNA Sequencing and Genomics Laboratory, Institute of Biotechnology, Helsinki, Finland.
Nanna FyhrquistInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Leena von HertzenUniversity of Helsinki, Helsinki, Finland.
Pekka JousilahtiDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Piia KarisolaHuman Microbiome Research (HUMI), Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Tiina LaatikainenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Jenni LehtimäkiFinnish Environment Institute, Helsinki, Finland.
Laura PaalanenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Lasse RuokolainenDepartment of Biosciences, University of Helsinki, Helsinki, Finland.
Kimmo SaarinenUniversity of Eastern Finland, Joensuu, Finland.
Erkka ValovirtaDepartment of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
Tuula VasankariDepartment of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
Tiina VlasoffNorth Karelia Centre for Public Health, Joensuu, Finland.
Marina ErholaPirkanmaa Joint Authority for Health Services and Social Welfare, Tampere, Finland.
Jean BousquetInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Erkki VartiainenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Mika J MäkeläSkin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.
University of Helsinki · FIFinnish Institute for Health and Welfare · FIUniversity of Eastern Finland · FIUniversity of Turku · FIFinnish Environment Institute · FIHumboldt-Universität zu Berlin · DEKarolinska Institutet · SENorth Karelia Central Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contact with natural environments enriches the human microbiome, promotes immune balance and protects against allergies and inflammatory disorders. In Finland, the allergy & asthma epidemic became slowly visible in mid 1960s. After the World War II, Karelia was split into Finnish and Soviet Union (now Russia) territories. This led to more marked environmental and lifestyle changes in the Finnish compared with Russian Karelia.

Indexed as

allergy epidemicallergy programmeasthmabiodiversity hypothesisclimate changeKarelia Allergy Studynature lossnon-communicable diseases

Identifiers

PMID36998574
PMCPMC10043497
OpenAlexW4324146562

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read24
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.