Evidence map›Paper›PMID 36998530›Full record

ReviewCritical care explorations2023

Neurologic Complications of Patients With COVID-19 Requiring Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis.

Cathy Meng Fei Li, Xiaoxiao Densy Deng, Yu Fei Ma, Emily Dawson, Carol Li, Dong Yao Wang, Lynn Huong, Teneille Gofton, Atul Dave Nagpal, Marat Slessarev

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care explorations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Cathy Meng Fei LiDepartment of Clinical Neurological Sciences, Western University, London, ON, Canada.
Xiaoxiao Densy DengSchulich School of Medicine and Dentistry, London, ON, Canada.
Yu Fei MaDivision of Neurology, Queen's University, Kingston, ON, Canada.
Emily DawsonDepartment of Medicine, Western University, London, ON, Canada.
Carol LiFaculty of Health Sciences, Western University, London, ON, Canada.
Dong Yao WangSchulich School of Medicine and Dentistry, London, ON, Canada.
Lynn HuongSchulich School of Medicine and Dentistry, London, ON, Canada.
Teneille GoftonDepartment of Clinical Neurological Sciences, Western University, London, ON, Canada.
Atul Dave NagpalDepartment of Medicine, Western University, London, ON, Canada.
Marat SlessarevDepartment of Medicine, Western University, London, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In COVID-19 patients requiring extracorporeal membrane oxygenation (ECMO), our primary objective was to determine the frequency of intracranial hemorrhage (ICH). Secondary objectives were to estimate the frequency of ischemic stroke, to explore association between higher anticoagulation targets and ICH, and to estimate the association between neurologic complications and in-hospital mortality. DATA SOURCES: We searched MEDLINE, Embase, PsycINFO, Cochrane, and MedRxiv databases from inception to March 15, 2022. STUDY SELECTION: We identified studies that described acute neurological complications in adult patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requiring ECMO. DATA EXTRACTION: Two authors independently performed study selection and data extraction. Studies with 95% or more of its patients on venovenous or venoarterial ECMO were pooled for meta-analysis, which was calculated using a random-effects model. DATA SYNTHESIS: Fifty-four studies (

conclusionsCOVID-19 patients requiring venovenous ECMO have a high frequency of ICH, and the development of neurologic complications more than doubled the risk of death. Healthcare providers should be aware of these increased risks and maintain a high index of suspicion for ICH.

Indexed as

COVID-19extracorporeal membrane oxygenationneurologic complications

Identifiers

PMID36998530
PMCPMC10047608

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.