Evidence map›Paper›PMID 36998299›Full record

ArticleAnnals of gastroenterological surgery2023

Importance of triple tumor markers as biomarkers in patients with pancreatic ductal adenocarcinoma.

Tadataka Takagi, Minako Nagai, Satoshi Nishiwada, Taichi Terai, Satoshi Yasuda, Yasuko Matsuo, Shunsuke Doi, Yuichiro Kohara, Masayuki Sho

Open access · goldAbstract read
In one paragraph

Article in Annals of gastroenterological surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tadataka TakagiDepartment of Surgery Nara Medical University Kashihara Japan.ORCID https://orcid.org/0000-0002-9340-2775
Minako NagaiDepartment of Surgery Nara Medical University Kashihara Japan.ORCID https://orcid.org/0000-0003-2102-1276
Satoshi NishiwadaDepartment of Surgery Nara Medical University Kashihara Japan.ORCID https://orcid.org/0000-0002-1462-7459
Taichi TeraiDepartment of Surgery Nara Medical University Kashihara Japan.
Satoshi YasudaDepartment of Surgery Nara Medical University Kashihara Japan.
Yasuko MatsuoDepartment of Surgery Nara Medical University Kashihara Japan.
Shunsuke DoiDepartment of Surgery Nara Medical University Kashihara Japan.
Yuichiro KoharaDepartment of Surgery Nara Medical University Kashihara Japan.
Masayuki ShoDepartment of Surgery Nara Medical University Kashihara Japan.ORCID https://orcid.org/0000-0002-6208-7661
Nara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: There is an urgent need to establish biomarkers for the treatment of pancreatic ductal adenocarcinoma (PDAC). The aim of this study was to investigate the usefulness of the combined assessment of carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), and duke pancreatic monoclonal antigen type 2 (DUPAN-2) in PDAC. Methods: We retrospectively investigated the impact of three tumor markers on overall survival (OS) and recurrence-free survival (RFS). Patients were classified into two groups: upfront surgery (US) and neoadjuvant chemoradiation (NACRT) groups. Results: In total, 310 patients were evaluated. In the US group, patients who had all three elevated markers showed a significantly worse prognosis than the others (median: 16.4 months, Conclusions: The combined evaluation of three tumor markers may provide useful information for the treatment of patients with PDAC.

Indexed as

biomarkerneoadjuvant chemoradiationpancreatic ductal adenocarcinomatumor markerupfront surgery

Identifiers

PMID36998299
PMCPMC10043775
OpenAlexW4304175401

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.