ReviewAnnals of gastroenterological surgery2023
Tumor deposits in colorectal cancer: Refining their definition in the TNM system.
Review in Annals of gastroenterological surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- CT staging performance in an international trial of neoadjuvant chemotherapy for locally advanced colon cancer.The British journal of radiology · 2025Trial
- Development and validation of a nomogram for preoperative prediction of tumor deposits in colorectal cancer.World journal of gastroenterology · 2023Trial
- Tumour deposits in colorectal carcinoma are associated with immune evasion and dose-dependent adverse prognosis beyond nodal status.British journal of cancer · 2026Article
- Independent prognostic value of tumor deposits in stage III colorectal cancer: a large-scale systematic review and meta-analysis.Journal of gastrointestinal oncology · 2026Article
- Do Tumor Deposits Demand More? Association of Chemotherapy Regimen Intensity with Survival Outcomes in N1 Colon Cancer Patients with Tumor Deposits.Annals of surgical oncology · 2026Article
- MRI-Based Differentiation of Tumor Deposits and Lymph Node Metastases in Rectal Cancer: A Systematic Review of Diagnostic Performance.Journal of clinical medicine · 2026Review
- Predictors of lymph node metastases, recurrence, and survival in patients with pedunculated-type T1 colorectal cancer.Journal of gastroenterology · 2026Article
- ASSOCIATION OF TUMOR DEPOSITS WITH TUMOR PATHOLOGY AND SURVIVAL IN GASTRIC CANCER: A CROSS-SECTIONAL STUDY.Arquivos de gastroenterologia · 2026Article
- Association between the histopathologic measurement of tumor-visceral peritoneal distance and prognosis in T3 colon adenocarcinoma.Pathology oncology research : POR · 2026Article
- Prognostic value of a modified lymph node ratio for combined colorectal cancer tumour deposits: a population-based study.Frontiers in oncology · 2026Article
- Stratifying prognosis in stage III colorectal cancer patients: the role of tumor deposits and lymph node ratio.Translational cancer research · 2025Article
- Article
- Axillary tumor deposits in primary breast carcinoma: a case report.Journal of medical case reports · 2025Article
- Lymph node mapping-based optimal bowel-resection margin and central radicality in colon cancer surgery: an international, prospective, observational cohort study.ESMO gastrointestinal oncology · 2025Article
- Prostate-Specific Membrane Antigen Expression in Colorectal Cancer and Its Potential Implication in Disease Monitoring in Rectal Cancer.Journal of gastrointestinal cancer · 2025Article
- Comparison of somatic mutations and clinicopathologic features of micropapillary and non-micropapillary colorectal carcinomas.BMC cancer · 2025Article
- Discriminating Tumor Deposits From Metastatic Lymph Nodes in Rectal Cancer: A Pilot Study Utilizing Dynamic Contrast-Enhanced MRI.Korean journal of radiology · 2025Article
- Prognostic value of tumor deposits and positive lymph nodes in colorectal cancer surgery: improved staging for long-term prognosis.BMC gastroenterology · 2025Article
- Lymph node or lymphoid aggregate? Impact on cancer resection quality, clinical prognosis, and tumor staging.Histology and histopathology · 2025Review
- Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients.BMC cancer · 2025Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor deposits (TDs) are discontinuous tumor spread in the mesocolon/mesorectum which is found in approximately 20% of colorectal cancer (CRC) and negatively affects survival. We have a history of repeated revisions on TD definition and categorization in the tumor-node-metastasis (TNM) system leading to stage migration. Since 1997, TDs have been categorized as T or N factors depending on their size (TNM5) or contour (TNM6). In 2009, TNM7 provided the category of N1c for TDs in a case without positive lymph nodes (LNs), which is also used in TNM8. However, increasing evidence suggests that these revisions are suboptimal and only "partially" successful. Specifically, the N1c rule is certainly useful for oncologists who are having difficulty with TDs in a case with no positive LNs. However, it has failed to maximize the value of the TNM system because of the underused prognostic information of individual TDs. Recently, the potential value of an alternative staging method has been highlighted in several studies using the "counting method." For this method, all nodular type TDs are individually counted together with positive LNs to derive the final pN, yielding a prognostic and diagnostic value that is superior to existing TNM systems. The TNM system has long stuck to the origin of TDs in providing its categorization, but it is time to make way for alternative options and initiate an international discussion on optimal treatment of TDs in tumor staging; otherwise, a proportion of patients end up missing an opportunity to receive the optimal adjuvant treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.