ArticleFrontiers in public health2023
Global, regional, and national incidence and mortality of neonatal sepsis and other neonatal infections, 1990-2019.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- High-frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term.The Cochrane database of systematic reviews · 2025Pooled it
- Using molecular methods to diagnose, classify, and treat neonatal sepsis: a scoping review.Frontiers in pediatrics · 2025Pooled it
- METTL7B Expression in Sepsis: Association With Disease Severity and 28-Day Mortality.Journal of clinical laboratory analysis · 2026Article
- Temporal trends and patterns in neonatal sepsis mortality across 194 countries, 2000-2021, with projections up to 2050.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Early-Onset Neonatal Sepsis: Clinical System Involvement and Maternal-Neonatal Risk Profiles in a Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Prospective genomic and epidemiologic surveillance of Klebsiella pneumoniae in a tertiary NICU.Antimicrobial resistance and infection control · 2026Article
- "Overview of Global Challenges in Dealing with Neonatal Sepsis and Responsibility of Healthcare Workers": A Narrative Review.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Review
- Early detection of microcirculatory changes using simultaneous heated and unheated transcutaneous blood gas monitoring: a proof-of-concept study in a porcine lipopolysaccharide model of systemic inflammation.Frontiers in medicine · 2026Article
- Trends in pathogens and antimicrobial resistance in culture-proven neonatal sepsis over a decade (2015-2024): the impact of COVID-19 pandemic.Frontiers in cellular and infection microbiology · 2026Observational
- Clinical and laboratory parameters associated with bloodstream infections among neonates admitted to a tertiary hospital in Tanzania: a hospital-based cross-sectional study.Frontiers in pediatrics · 2026Article
- Development and Validation of a 28-Day Mortality Prediction Model for Patients with Sepsis Complicated by Autoimmune Diseases Using Two Machine Learning Methods.Journal of inflammation research · 2026Article
- Article
- Ferritinophagy-related prognostic genes UBE2Q1, NEDD4L, and TCP11L2 for prognosis prediction in sepsis.Scientific reports · 2025Article
- Prevalence and risk factors of neonatal sepsis in the neonatal intensive care unit at Soroti Regional Referral hospital, Uganda: a retrospective study.BMC pregnancy and childbirth · 2025Article
- A Cohort Study on Clinical Features and Microbiological Profile in Neonatal Sepsis in Southwest of Iran.Health science reports · 2025Article
- Global, regional, and national incidence and mortality of neonatal sepsis and other neonatal infections, 1990-2021 and predictions to 2050.BMC pediatrics · 2025Article
- Development of a mouse model forMicrobiology spectrum · 2025Article
- RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch.Journal of inflammation (London, England) · 2025Article
- Survival of the Littlest: Navigating Sepsis Diagnosis beyond Inflammation in Preterm Neonates.Journal of proteome research · 2025Article
- METTL3-mediated m6A modification in sepsis: current evidence and future perspectives.Epigenomics · 2025Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neonatal infections, especially neonatal sepsis, are one of the major causes of incidence and mortality in pediatrics. However, the global burden of neonatal sepsis and other neonatal infections (NSNIs) remains unclear. Methods: From the 2019 global disease burden study, we collected annual incident cases, deaths, age-standardized incidence rates (ASIRs), and age-standardized deaths rates (ASDRs) of NSNIs in the past 30 years. Analysis indicators included the percentage of relative changes in incident cases and deaths, and the estimated annual percentage changes (EAPCs) of ASIRs and ASDRs. Correlations were assessed between the EAPCs of ASIRs and ASDRs and social evaluation indicators, including sociodemographic index (SDI) and universal health coverage index (UHCI). Results: Globally, the number of incident cases of NSNIs grew by 12.79% per year, and the number of deaths dropped by 12.93% per year. During this period, global ASIR of NSNIs increased by 46% annually on average, while ASDR decreased by 53% annually on average. The ASIR and ASDR of female NSNIs were consistently lower than that of male NSNIs. The EAPC of female ASIR was 0.61, nearly twice that of male ASIR, and female ASIR was growing rapidly. The same declining trends of ASDR were noted in males and females. The ASIR of NSNIs in high-SDI regions grew by an average of 14% annually from 1990 to 2019. Except for high-SDI regions, the ASIRs of other 4 SDI regions maintained a rising trend at a high level, and were improved in the past 10 years. The ASDRs of all 5 SDI regions generally showed a downward trend. The region with the highest ASIR of NSNIs was Andean Latin America, and Western Sub-Saharan Africa had the highest mortality. We found a negative correlation between EAPCs of ASDRs and UHCI in 2019. Conclusion: The global health situation was still not optimal. The incidence of NSNIs remained high, and continues to rise. The mortality of NSNIs has decreased, especially in the countries/territories with high UHCI. Therefore, it is crucial to improve the overall awareness and management of NSNIs, and take interventions for NSNIs worldwide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.