Evidence map›Paper›PMID 36998234›Full record

ArticleNeurocase

Behavioral variant frontotemporal dementia in a 23-year-old man.

Tania C Ghazarian, Matthew G H Hall, Leslie A Horton, Bruce L Miller, Robert T Rubin

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocase. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tania C GhazarianCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA.
Matthew G H HallWeill Institute for Neurosciences, Department of Neurology, and Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Leslie A HortonPsychiatry Residency Program, Community Memorial Healthcare, Ventura, CA, USA.
Bruce L MillerWeill Institute for Neurosciences, Department of Neurology, and Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
Robert T RubinPsychiatry Residency Program, Community Memorial Healthcare, Ventura, CA, USA.
University of California, San Francisco · USVentura County Medical Center · USWestern University of Health Sciences · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
NIA NIH HHS P01 AG019724
6 · The paper itself

Abstract

A 23-year-old man presented with behavioral disinhibition, stereotypies, motor apathy, flattened affect, and inappropriate laughter. CT demonstrated generalized cerebral atrophy. He was admitted with a diagnosis of unspecified psychosis and discharged on antipsychotic medication. He was readmitted 3 months later, was diagnosed with schizophrenia, and antipsychotic medication was continued. Owing to symptom progression and aggressive behavior, he was readmitted 2 months later. CT again demonstrated moderate central and cortical cerebral atrophy. MRI showed severe, stable atrophy with frontotemporal predominance, and he was diagnosed with probable behavioral variant frontotemporal dementia (bvFTD).  Over the next year he rapidly deteriorated, with loss of cognitive abilities. Genetic testing revealed several variants, none of which are clearly disease-causing.

Indexed as

Antipsychotic AgentsApathyFrontotemporal DementiaAdultAtrophyHumansMagnetic Resonance ImagingMaleNeuropsychological TestsYoung AdultAntipsychotic Agentsbehavioral variantdementiaearly dementiaFrontotemporal dementiapsychosis

Identifiers

PMID36998234
PMCPMC10544695
OpenAlexW4362458433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.