Evidence map›Paper›PMID 36998060›Full record

ArticleBioelectronic medicine2023

Brief periods of transcutaneous auricular vagus nerve stimulation improve autonomic balance and alter circulating monocytes and endothelial cells in patients with metabolic syndrome: a pilot study.

Tercio Lemos de Moraes, Fernando Oliveira Costa, Danielly Gomes Cabral, Daniella Marques Fernandes, Carine Teles Sangaleti, Maria Aparecida Dalboni, Josiane Motta E Motta, Liliane Appratto de Souza, Nicola Montano, Maria Claudia Irigoyen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioelectronic medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Tercio Lemos de MoraesNove de Julho University - UNINOVE, São Paulo, Brazil.
Fernando Oliveira CostaNove de Julho University - UNINOVE, São Paulo, Brazil.
Danielly Gomes CabralNove de Julho University - UNINOVE, São Paulo, Brazil.
Daniella Marques FernandesNove de Julho University - UNINOVE, São Paulo, Brazil.
Carine Teles SangaletiMidwestern State University (UNICENTRO), Paraná, Brazil.
Maria Aparecida DalboniNove de Julho University - UNINOVE, São Paulo, Brazil.
Josiane Motta E MottaNove de Julho University - UNINOVE, São Paulo, Brazil.
Liliane Appratto de SouzaInstitute of Cardiology of Rio Grande Do Sul, Porto Alegre, Brazil.
Nicola MontanoDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Maria Claudia IrigoyenUniversity of São Paulo, Hypertension Unit, São Paulo, Brazil.
Michael BrinesThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Kevin J TraceyThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Valentin A PavlovThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Fernanda M Consolim ColomboNove de Julho University - UNINOVE, São Paulo, Brazil. fernanda.consolim@incor.usp.br.ORCID http://orcid.org/0000-0003-3220-019X
Universidade Nove de Julho · BRNorthwell Health · USUniversidade de São Paulo · BRUniversidade Estadual do Centro-Oeste · BRUniversity of Milan · IT

Funding

Brainstem Cholinergic Circuitries in the Inflammatory Reflex during SepsisR01GM128008 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PAVLOV, VALENTIN ATANASSOV · 2018 to 2022
$1.8M
NIGMS NIH HHS R01 GM128008
6 · The paper itself

Abstract

backgroundThere is emerging evidence that the nervous system regulates immune and metabolic alterations mediating Metabolic syndrome (MetS) pathogenesis via the vagus nerve. This study evaluated the effects of transcutaneous auricular vagus nerve stimulation (TAVNS) on key cardiovascular and inflammatory components of MetS.

methodsWe conducted an open label, randomized (2:1), two-arm, parallel-group controlled trial in MetS patients. Subjects in the treatment group (n = 20) received 30 min of TAVNS with a NEMOS® device placed on the cymba conchae of the left ear, once weekly. Patients in the control group (n = 10) received no stimulation. Hemodynamic, heart rate variability (HRV), biochemical parameters, and monocytes, progenitor endothelial cells, circulating endothelial cells, and endothelial micro particles were evaluated at randomization, after the first TAVNS treatment, and again after 8 weeks of follow-up.

resultsAn improvement in sympathovagal balance (HRV analysis) was observed after the first TAVNS session. Only patients treated with TAVNS for 8 weeks had a significant decrease in office BP and HR, a further improvement in sympathovagal balance, with a shift of circulating monocytes towards an anti-inflammatory phenotype and endothelial cells to a reparative vascular profile.

conclusionThese results are of interest for further study of TAVNS as treatment of MetS.

Indexed as

Cardiovascular autonomic controlEndothelial dysfunctionInflammationMetabolic syndromeMonocyteTranscutaneous auricular vagus nerve stimulation

Identifiers

PMID36998060
PMCPMC10064781
OpenAlexW4362506642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.