Evidence map›Paper›PMID 36998014›Full record

ArticleBreast cancer research : BCR2023

Clinical and biological heterogeneities in triple-negative breast cancer reveals a non-negligible role of HER2-low.

Xi E Hu, Ping Yang, Songhao Chen, Gang Wei, Lijuan Yuan, Zhenyu Yang, Li Gong, Li He, Lin Yang, Shujia Peng and 3 more

Open access · goldAbstract read
In one paragraph

Article in Breast cancer research : BCR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
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  3. Utilization of MRI-based radiomics nomogram for predicting HER2-zero, -low, and -overexpression breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  6. SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  14. ECSCR functions as a potential tumor suppressor in breast cancer cells.Medical oncology (Northwood, London, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Xi E Hu *Department of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Ping Yang *Department of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Songhao Chen *Department of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Gang WeiDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Lijuan YuanDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Zhenyu YangDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Li GongDepartment of Pathology, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Li HeDepartment of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Lin YangDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Shujia PengDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Yanming DongDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China.
Xianli HeDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China. wanghe@fmmu.edu.cn.
Guoqiang BaoDepartment of General Surgery, The Second Affiliated Hospital of Air Force Medical University, No. 569, Xinsi Road, Baqiao District, Xi'an, Shannxi, China. guoqiang@fmmu.edu.cn.
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHER2-low could be found in some patients with triple-negative breast cancer (TNBC). However, its potential impacts on clinical features and tumor biological characteristics in TNBC remain unclear.

methodsWe enrolled 251 consecutive TNBC patients retrospectively, including 157 HER2-low (HER2

resultsCompared with HER2

conclusionsThis study suggests that HER2

Indexed as

Breast NeoplasmsTriple Negative Breast NeoplasmsFemaleHumansKi-67 AntigenPrognosisRetrospective StudiesTumor MicroenvironmentKi-67 AntigenHER2-lowHeterogeneityPrognosisSingle-cell RNA sequencingTriple-negative breast cancerTumor microenvironment

Identifiers

PMID36998014
PMCPMC10061837
OpenAlexW4361268148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.