Evidence map›Paper›PMID 36997764›Full record

ArticleInflammation2023

Cross-Talk between Mucosal-Associated Invariant T, Natural Killer, and Natural Killer T Cell Populations is Implicated in the Pathogenesis of Placenta Accreta Spectrum.

Omnia El-Badawy, Ahmed M Abbas, Eman Radwan, Rania Makboul, Areej A Khamis, Maha Ali, Mai M Elkabsh, Marwa H Bakr, Asmaa M Zahran

Open access · hybridAbstract read
In one paragraph

Article in Inflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Omnia El-BadawyDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt. omniaalbadawy@aun.edu.eg.ORCID http://orcid.org/0000-0001-8445-711X
Ahmed M AbbasObstetrics and Gynecology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Eman RadwanDepartment of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.
Rania MakboulPathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Areej A KhamisObstetrics and Gynecology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Maha AliDepartment of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mai M ElkabshPathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Marwa H BakrDepartment of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Asmaa M ZahranDepartment of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Assiut University · EG

Funding

Faculty of Medicine, Grant Office, Assiut University 2020-06-01-003
6 · The paper itself

Abstract

The study included 32 women with PAS and 20 with normally implanted placenta as a control group. Vascular endothelial cell growth factor (VEGF), Soluble FMS Like Tyrosine Kinase (sFLT-1/sVEGFR1), and Endoglin (ENG) were measured in placenta tissue by ELISA. Granzyme B (GrzB) expression in trophoblastic and stromal mesenchymal cells was evaluated by immunohistochemistry. MAIT, NK, and NKT cells were assessed in blood and placenta by flow cytometry. Alterations were observed in levels of MAIT cells, NK cell subsets, and NKT cells in patients compared with controls. Several significant correlations were detected between these cells and GrzB scores, VEGF, ENG, and sFLT-1 levels. This is the first study analysing these cells in PAS patients and correlating their levels with changes in some angiogenic and antiangiogenic factors implicated in trophoblast invasion and with GrzB distribution in trophoblast and stroma. Interrelation between these cells probably plays an important role in pathogenesis of PAS.

Indexed as

Natural Killer T-CellsPlacenta AccretaPre-EclampsiaEndoglinFemaleHumansPlacentaPregnancyTrophoblastsVascular Endothelial Growth Factor AEndoglinVascular Endothelial Growth Factor AENGMAITNK cellsNKT cellsplacenta accreta spectrumsFLT-1VEGF

Identifiers

PMID36997764
PMCPMC10359234
OpenAlexW4362458838

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.