ArticleNature neuroscience2023
Norepinephrine links astrocytic activity to regulation of cortical state.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
78 citing papers in PubMed, 116 citations in OpenAlex.
- Context-Dependent modulation of astrocytic CaJournal of computational neuroscience · 2026Article
- Hippocampal astrocytic sequences emerge during learning and memory recall.Nature neuroscience · 2026Article
- Microglia stabilize sleep homeostasis via adenosine AScience advances · 2026Article
- Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility.Acta pharmacologica Sinica · 2026Article
- Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid-Beta Pathology in Alzheimer's Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dorsal striatal circuit mechanisms contributing to astrocyte modulation of alcohol-related behaviors.bioRxiv : the preprint server for biology · 2026Article
- The multiple scales of astrocytic functional units.Nature neuroscience · 2026Review
- Hippocampal astrocytic sequences emerge during learning and memory.bioRxiv : the preprint server for biology · 2026Article
- Cellular and molecular mechanisms of astrocyte plasticity in learning and memory.Trends in neurosciences · 2026Review
- Inferring norepinephrine dynamics from partial observations reveals the temporal structure of elevations during arousal.bioRxiv : the preprint server for biology · 2026Article
- Article
- Astrocytes in predictive processing of emotion: Kir4.1 as precision modulator of social interaction.Acta pharmaceutica Sinica. B · 2026Article
- Next-generation multicolor indicators for in vivo imaging of norepinephrine.Nature methods · 2026Article
- Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli.Journal of neurophysiology · 2026Article
- Multi-scale imaging and recording of in-vivo neural activity.BMB reports · 2026Review
- The emerging role of astrocytes in spatial cognition, action and Alzheimer's disease.Frontiers in cellular neuroscience · 2026Review
- Glial syncytial control fields and the low-frequency resonome of the human brain.Frontiers in human neuroscience · 2026Article
- Amyloid-Frontiers in neuroscience · 2026Review
- State-space kinetic Ising model reveals task-dependent entropy flow in sparsely active nonequilibrium neuronal dynamics.Nature communications · 2025Article
- In Vitro Pharmacology of Mitragynine at α-Adrenoceptors.ACS chemical neuroscience · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Cortical state, defined by population-level neuronal activity patterns, determines sensory perception. While arousal-associated neuromodulators-including norepinephrine (NE)-reduce cortical synchrony, how the cortex resynchronizes remains unknown. Furthermore, general mechanisms regulating cortical synchrony in the wake state are poorly understood. Using in vivo imaging and electrophysiology in mouse visual cortex, we describe a critical role for cortical astrocytes in circuit resynchronization. We characterize astrocytes' calcium responses to changes in behavioral arousal and NE, and show that astrocytes signal when arousal-driven neuronal activity is reduced and bi-hemispheric cortical synchrony is increased. Using in vivo pharmacology, we uncover a paradoxical, synchronizing response to Adra1a receptor stimulation. We reconcile these results by demonstrating that astrocyte-specific deletion of Adra1a enhances arousal-driven neuronal activity, while impairing arousal-related cortical synchrony. Our findings demonstrate that astrocytic NE signaling acts as a distinct neuromodulatory pathway, regulating cortical state and linking arousal-associated desynchrony to cortical circuit resynchronization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.