Evidence map›Paper›PMID 36997729›Full record

ReviewInflammopharmacology2023

Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases.

Mahvash Sadeghi, Sajad Dehnavi, Ali Asadirad, Suowen Xu, Muhammed Majeed, Tannaz Jamialahmadi, Thomas P Johnston, Amirhossein Sahebkar

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Inflammopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 6 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 6 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Mahvash SadeghiDepartment of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Sajad DehnaviDepartment of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ali AsadiradDepartment of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Suowen XuDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Muhammed MajeedSabinsa Corporation, East Windsor, NJ, USA.
Tannaz JamialahmadiSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Thomas P JohnstonDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.
Amirhossein SahebkarApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sahebkara@mums.ac.ir.ORCID http://orcid.org/0000-0002-8656-1444
Mashhad University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IRSabin Vaccine Institute · USUniversity of Missouri–Kansas City · USUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the induction of angiogenesis and maintenance of hemostasis. Curcumin, the major component of the Curcuma longa rhizome, has various pharmacological actions, including anti-inflammatory, immune-regulatory, anti-oxidative, and lipid-modifying properties. Chemokines and chemokine receptors are influenced/modulated by curcumin. Thus, the current review focuses on the molecular mechanisms associated with curcumin's effects on chemoattractant cytokines, as well as putting into context the many studies that have reported curcumin-mediated regulatory effects on inflammatory conditions in the organs/systems of the body (e.g., the central nervous system, liver, and cardiovascular system). Curcumin's effects on viral and bacterial infections, cancer, and adverse pregnancy outcomes are also reviewed.

Indexed as

CurcuminAnti-Inflammatory AgentsChemokinesCurcumaCytokinesLiverAnti-Inflammatory AgentsChemokinesCurcuminCytokinesCancerChemokineCurcuminCytokineInfectionInflammation

Identifiers

PMID36997729
PMCPMC10062691
OpenAlexW4362460075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.