ArticleGeroScience2023
Can frailty scores predict the incidence of cancer? Results from two large population-based studies.
Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Integrative prediction of Alzheimer's disease and related dementias using multi-omics aging clocks and genetic data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Interacting and joint effects of frailty and depressive symptoms in relation to risk of cardio-oncology comorbidity in older adults from three prospective cohorts.BMC geriatrics · 2026Article
- Deficit accumulation frailty and risk of incident chronic kidney disease: a prospective analysis of the UK biobank and CHARLS cohorts.International urology and nephrology · 2026Article
- Frailty index predicts the risk of 17 health outcomes in distinct ways: prospective findings from the Moli-sani Study.Age and ageing · 2026Article
- Does Modified 5-Item Frailty Index Correlate With Survival in Oropharyngeal Squamous Cell Carcinoma?Head & neck · 2026Article
- Healthy lifestyle reduces frailty-associated overall and site-specific cancer risks: a prospective large cohort study in Chinese adults.Journal of translational medicine · 2025Article
- Large language model-based biological age prediction in large-scale populations.Nature medicine · 2025Article
- Patient-reported pain severity is associated with shorter survival in older adults with newly diagnosed cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Walking Speed and Risk of Cancer in Two Prospective Cohort Studies.Journal of cachexia, sarcopenia and muscle · 2025Article
- Association of frailty and its trajectory with the risk of cancer: evidence from the China health and retirement longitudinal study (CHARLS).BMC public health · 2025Article
- Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications.Nutrients · 2025Review
- Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing.Age and ageing · 2025Article
- Pre-frailty is associated with higher risk of gastroesophageal reflux disease: a large prospective cohort study.Scientific reports · 2025Article
- Genetically predicted frailty index and risk of cutaneous melanoma: a two-sample Mendelian randomization study.Archives of dermatological research · 2024Article
- Impact of Masticatory Performance and the Tongue-Lip Motor Function on Incident Adverse Health Events in Patients with Metabolic Disease.Journal of atherosclerosis and thrombosis · 2024Article
- Frailty predicts all-cause and cause-specific mortality among older adults in Austria: 8-year mortality follow-up of the Austrian Health Interview Survey (ATHIS 2014).BMC geriatrics · 2024Article
- Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function.Frontiers in aging neuroscience · 2024Article
- Exploring Frailty in the Intersection of Cardiovascular Disease and Cancer in Older People.International journal of environmental research and public health · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While chronological age is the single biggest risk factor for cancer, it is less clear whether frailty, an age-related state of physiological decline, may also predict cancer incidence. We assessed the associations of frailty index (FI) and frailty phenotype (FP) scores with the incidence of any cancer and five common cancers (breast, prostate, lung, colorectal, melanoma) in 453,144 UK Biobank (UKB) and 36,888 Screening Across the Lifespan Twin study (SALT) participants, who aged 38-73 years and had no cancer diagnosis at baseline. During a median follow-up of 10.9 and 10.7 years, 53,049 (11.7%) and 4,362 (11.8%) incident cancers were documented in UKB and SALT, respectively. Using multivariable-adjusted Cox models, we found a higher risk of any cancer in frail vs. non-frail UKB participants, when defined by both FI (hazard ratio [HR] = 1.22; 95% confidence interval [CI] = 1.17-1.28) and FP (HR = 1.16; 95% CI = 1.11-1.21). The FI in SALT similarly predicted risk of any cancer (HR = 1.31; 95% CI = 1.15-1.49). Moreover, frailty was predictive of lung cancer in UKB, although this association was not observed in SALT. Adding frailty scores to models including age, sex, and traditional cancer risk factors resulted in little improvement in C-statistics for most cancers. In a within-twin-pair analysis in SALT, the association between FI and any cancer was attenuated within monozygotic but not dizygotic twins, indicating that it may partly be explained by genetic factors. Our findings suggest that frailty scores are associated with the incidence of any cancer and lung cancer, although their clinical utility for predicting cancers may be limited.
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