ArticleScientific reports2023
Respiratory brain impulse propagation in focal epilepsy.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Sleep Alters the Velocity of Physiological Brain Pulsations in Humans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sleep alters neurovascular and hydrodynamic coupling in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Brain Pulsation Imaging Using Non-Balanced Steady-State Free Precession With 3D-EPI Readout.Magnetic resonance in medicine · 2026Article
- Reduced BOLD-CSF coupling as a potential functional imaging correlate of semantic fluency decline in MRI-negative temporal lobe epilepsy.Frontiers in aging neuroscience · 2026Article
- Glymphatic system dysfunction in temporal lobe epilepsy with hippocampal sclerosis: MRI-based evaluation of circulatory markers and disease progression.Frontiers in neuroscience · 2026Article
- Review
- Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power.Acta ophthalmologica · 2025Article
- Ultrafast Imaging of Physiological Brain Pulsations With Magnetic Resonance Encephalography-From Noise to Predictive Clinical Biomarker.NMR in biomedicine · 2025Review
- Association of body-mass index with physiological brain pulsations across adulthood - a fast fMRI study.International journal of obesity (2005) · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory brain pulsations pertaining to intra-axial hydrodynamic solute transport are markedly altered in focal epilepsy. We used optical flow analysis of ultra-fast functional magnetic resonance imaging (fMRI) data to investigate the velocity characteristics of respiratory brain impulse propagation in patients with focal epilepsy treated with antiseizure medication (ASM) (medicated patients with focal epilepsy; ME, n = 23), drug-naïve patients with at least one seizure (DN, n = 19) and matched healthy control subjects (HC, n = 75). We detected in the two patient groups (ME and DN) several significant alterations in the respiratory brain pulsation propagation velocity, which showed a bidirectional change dominated by a reduction in speed. Furthermore, the respiratory impulses moved more in reversed or incoherent directions in both patient groups vs. the HC group. The speed reductions and directionality changes occurred in specific phases of the respiratory cycle. In conclusion, irrespective of medication status, both patient groups showed incoherent and slower respiratory brain impulses, which may contribute to epileptic brain pathology by hindering brain hydrodynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.