ReviewMolecular psychiatry2023
Pathways to the persistence of drug use despite its adverse consequences.
Review in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Brain Architecture of Punishment Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- Improving translational insight using sequential sampling models in drug choice.Psychopharmacology · 2026Review
- Disinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Self-Deception in Addiction Rehabilitation: Impulsivity and Self-Efficacy as Predictors of Manipulation and Mystification.Behavioral sciences (Basel, Switzerland) · 2026Article
- The relationship between regular substance use and cost comparisons in stable and volatile learning contexts.Translational psychiatry · 2026Article
- In vitro metabolic fate of 1-[3-(trimethylsilyl)propanoyl] lysergic acid diethylamide (1S-LSD), a silicon-containing LSD analog.Forensic toxicology · 2026Article
- Instrumental learning enhances the intrinsic excitability of basal amygdala projection neurons.Learning & memory (Cold Spring Harbor, N.Y.) · 2026Article
- Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Methamphetamine Use, Post-Traumatic Stress, and Substance Use Consequences Among American Indians with a Substance Use Problem.Substance use & misuse · 2026Article
- Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.Brain structure & function · 2025Review
- The psychedelic (-)-2,5-dimethoxy-4-iodoamphetamine [(-)-DOI] demonstrates efficacy in reducing cocaine reward and motivation in male rats.Psychopharmacology · 2025Article
- Mechanistic and translational insights from preclinical cocaine choice procedures on the economic substitutability of cocaine and nondrug reinforcers.Neuroscience and biobehavioral reviews · 2025Review
- Causal inference and cognitive-behavioral integration deficits drive stable variation in human punishment sensitivity.Communications psychology · 2025Article
- Current interpretations of the I-PACE model of behavioral addictions.Journal of behavioral addictions · 2025Review
- Role of serotonin neurons in the dorsal raphe nucleus in heroin self-administration and punishment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Mind the G(ap): bridging prevention needs and approaches for GHB/GBL users and their social environment.Harm reduction journal · 2025Article
- Individual differences in prelimbic neural representation of food and cocaine seeking.Cell reports · 2024Article
- Impact of provoked stress on model-free and model-based reinforcement learning in individuals with alcohol use disorder.Addictive behaviors reports · 2024Article
- The selective DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The persistence of drug taking despite its adverse consequences plays a central role in the presentation, diagnosis, and impacts of addiction. Eventual recognition and appraisal of these adverse consequences is central to decisions to reduce or cease use. However, the most appropriate ways of conceptualizing persistence in the face of adverse consequences remain unclear. Here we review evidence that there are at least three pathways to persistent use despite the negative consequences of that use. A cognitive pathway for recognition of adverse consequences, a motivational pathway for valuation of these consequences, and a behavioral pathway for responding to these adverse consequences. These pathways are dynamic, not linear, with multiple possible trajectories between them, and each is sufficient to produce persistence. We describe these pathways, their characteristics, brain cellular and circuit substrates, and we highlight their relevance to different pathways to self- and treatment-guided behavior change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.