Evidence map›Paper›PMID 36997530›Full record

ArticleNature communications2023

Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8

André Santa Cruz, Ana Mendes-Frias, Marne Azarias-da-Silva, Sónia André, Ana Isabel Oliveira, Olga Pires, Marta Mendes, Bárbara Oliveira, Marta Braga, Joana Rita Lopes and 12 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025
    Pooled it
  2. Persistent cytolytic CD8Cell reports. Medicine · 2026
    Article
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  15. Article
  16. Targeting the SARS-CoV-2 reservoir in long COVID.The Lancet. Infectious diseases · 2025
    Review
  17. Article
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 3 countries.

André Santa Cruz *Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. andrescjoao@med.uminho.pt.ORCID 0000-0002-5636-575X
Ana Mendes-Frias *Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Marne Azarias-da-SilvaINSERM-U1124, Université Paris Cité, Paris, France.ORCID 0009-0006-3411-1835
Sónia AndréINSERM-U1124, Université Paris Cité, Paris, France.
Ana Isabel OliveiraDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.
Olga PiresDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.
Marta MendesDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.
Bárbara OliveiraDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.ORCID 0000-0002-3096-0139
Marta BragaDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.
Joana Rita LopesDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.ORCID 0000-0002-1503-6714
Rui DominguesDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.
Ricardo CostaDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.
Luís Neves SilvaDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.ORCID 0000-0001-5045-5634
Ana Rita MatosDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.
Cristina ÂngelaDepartment of Internal Medicine, Hospital of Braga, Braga, Portugal.
Patrício CostaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0002-1201-9177
Alexandre CarvalhoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Carlos CapelaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Jorge PedrosaLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
António Gil CastroLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Jérôme EstaquierINSERM-U1124, Université Paris Cité, Paris, France. estaquier@yahoo.fr.ORCID 0000-0002-9432-8044
Ricardo SilvestreLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. ricardosilvestre@med.uminho.pt.ORCID 0000-0002-9270-2717
Hospital Braga · PTUniversity of Minho · PTInserm · FR

Funding

CIHR FRN-177760
6 · The paper itself

Abstract

Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2 condition (PASC) that persists for months after infection. Here we evaluate the immune response in convalescent individuals with PASC compared to convalescent asymptomatic and uninfected participants, six months following their COVID-19 diagnosis. Both convalescent asymptomatic and PASC cases are characterised by higher CD8

Indexed as

COVID-19SARS-CoV-2Acute DiseaseCD8-Positive T-LymphocytesCOVID-19 TestingDisease ProgressionHumansImmunoglobulin AIntegrin beta ChainsImmunoglobulin Aintegrin beta7Integrin beta Chains

Identifiers

PMID36997530
PMCPMC10061413
OpenAlexW4361273095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.