Evidence map›Paper›PMID 36997513›Full record

ArticleSignal transduction and targeted therapy2023

Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis.

Ping Zhang, Ji Dong, Xiaoying Fan, Jun Yong, Ming Yang, Yunsong Liu, Xiao Zhang, Longwei Lv, Lu Wen, Jie Qiao and 2 more

Open access · goldAbstract read
In one paragraph

Article in Signal transduction and targeted therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. [Advances in oral and craniofacial bone regeneration modulated by stem cells and biomaterials].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
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  17. Modeling of skeletal development and diseases using human pluripotent stem cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Review
  18. Article
  19. Article
  20. N-CADHERINStem cell research & therapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Ping Zhang *Department of Prosthodontics, Peking University School and Hospital of Stomatology, 100081, Beijing, China.
Ji Dong *Guangzhou Laboratory, 510005, Guangzhou, China.ORCID 0000-0002-8953-5284
Xiaoying Fan *Guangzhou Laboratory, 510005, Guangzhou, China.
Jun YongBeijing Advanced Innovation Center for Genomics, School of Life Sciences, Department of Obstetrics and Gynecology, Third Hospital, Peking University, 100871, Beijing, China.
Ming YangBeijing Advanced Innovation Center for Genomics, School of Life Sciences, Department of Obstetrics and Gynecology, Third Hospital, Peking University, 100871, Beijing, China.
Yunsong LiuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, 100081, Beijing, China.
Xiao ZhangDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, 100081, Beijing, China.
Longwei LvDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, 100081, Beijing, China.
Lu WenBiomedical Pioneering Innovation Center and Center for Reproductive Medicine, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, 100871, Beijing, China.
Jie QiaoBeijing Advanced Innovation Center for Genomics, School of Life Sciences, Department of Obstetrics and Gynecology, Third Hospital, Peking University, 100871, Beijing, China. jie.qiao@263.net.
Fuchou TangBiomedical Pioneering Innovation Center and Center for Reproductive Medicine, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, 100871, Beijing, China. tangfuchou@pku.edu.cn.
Yongsheng ZhouDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, 100081, Beijing, China. kqzhouysh@hsc.pku.edu.cn.ORCID 0000-0002-4332-0878
Peking University · CNGuangzhou Experimental Station · CNNational Clinical Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone marrow mesenchymal stromal/stem cells (MSCs) are a heterogeneous population that can self-renew and generate stroma, cartilage, fat, and bone. Although a significant progress has been made toward recognizing about the phenotypic characteristics of MSCs, the true identity and properties of MSCs in bone marrow remain unclear. Here, we report the expression landscape of human fetal BM nucleated cells (BMNCs) based on the single-cell transcriptomic analysis. Unexpectedly, while the common cell surface markers such as CD146, CD271, and PDGFRa used for isolating MSCs were not detected, LIFR

Indexed as

Bone MarrowMesenchymal Stem CellsBone Marrow CellsHumansReceptor, Platelet-Derived Growth Factor betaTranscriptomeReceptor, Platelet-Derived Growth Factor beta

Identifiers

PMID36997513
PMCPMC10063684
OpenAlexW4361244550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.