Evidence map›Paper›PMID 36997341›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Metal-Organic Layer Delivers 5-Aminolevulinic Acid and Porphyrin for Dual-Organelle-Targeted Photodynamic Therapy.

Taokun Luo, Yingjie Fan, Jianming Mao, Xiaomin Jiang, Luciana Albano, Eric Yuan, Tomas Germanas, Wenbin Lin

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Taokun LuoDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Yingjie FanDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Jianming MaoDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Xiaomin JiangDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Luciana AlbanoDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Eric YuanDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Tomas GermanasDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Wenbin LinDepartment of Chemistry, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-7035-7759
University of Chicago · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck CancersR01CA253655 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN, WEICHSELBAUM, RALPH R · 2020 to 2024
$2.5M
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA253655
6 · The paper itself

Abstract

The efficacy of photodynamic therapy (PDT) depends on the subcellular localization of photosensitizers. Herein, we report a dual-organelle-targeted nanoparticle platform for enhanced PDT of cancer. By grafting 5-aminolevulinic acid (ALA) to a Hf

Indexed as

PhotochemotherapyPorphyrinsAminolevulinic AcidCell Line, TumorMetalsMitochondriaPhotosensitizing AgentsAminolevulinic AcidMetalsPhotosensitizing AgentsPorphyrins5-Aminolevulinic AcidCancer TherapyMetal-Organic LayerOrganelle TargetingPhotodynamic Therapy

Identifiers

PMID36997341
PMCPMC10325034
OpenAlexW4361260109

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.