Evidence map›Paper›PMID 36997329›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

PSMA PET Tumor-to-Salivary Gland Ratio to Predict Response to [

Masatoshi Hotta, Andrei Gafita, Vishnu Murthy, Matthias R Benz, Ida Sonni, Irene A Burger, Matthias Eiber, Louise Emmett, Andrea Farolfi, Wolfgang P Fendler and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Quantitative PSMA PET Biomarkers for Predicting Response toJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Pooled it
  3. Pooled it
  4. Prognostic Value of Posttherapy SPECT/CT for Overall Survival in Patients Undergoing [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  5. Article
  6. Article
  7. Baseline PSMA PET/CT Biomarkers for Patient Selection in [Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  8. Article
  9. PSMA PET/CT-Derived Indicators and Outcomes After [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Visual and QuantitativeMolecular imaging and biology · 2025
    Article
  15. Radionuclides Landscape in Prostate Cancer Theranostics.International journal of molecular sciences · 2025
    Review
  16. Review
  17. Review
  18. Study of predictive factors for response toFrontiers in medicine · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Masatoshi HottaAhmanson Translational Theranostics Division, UCLA, Los Angeles, California; mhotta.11.11@gmail.com.
Andrei GafitaAhmanson Translational Theranostics Division, UCLA, Los Angeles, California.
Vishnu MurthyAhmanson Translational Theranostics Division, UCLA, Los Angeles, California.
Matthias R BenzAhmanson Translational Theranostics Division, UCLA, Los Angeles, California.
Ida SonniAhmanson Translational Theranostics Division, UCLA, Los Angeles, California.
Irene A BurgerDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Matthias EiberDepartment of Nuclear Medicine, Technical University Munich, Munich, Germany.
Louise EmmettDepartment of Theranostics and Nuclear Medicine, St. Vincent's Hospital, Sydney, New South Wales, Australia.
Andrea FarolfiAhmanson Translational Theranostics Division, UCLA, Los Angeles, California.
Wolfgang P FendlerDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium-University Hospital Essen, Essen, Germany.
Manuel M WeberDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium-University Hospital Essen, Essen, Germany.
Michael S HofmanProstate Cancer Theranostics and Imaging Centre of Excellence, Molecular Imaging Therapeutic Nuclear Medicine, Cancer Imaging, Peter MacCallum Cancer Centre, and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
Thomas A HopeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California; and.
Clemens KratochwilDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Johannes CzerninAhmanson Translational Theranostics Division, UCLA, Los Angeles, California.
Jeremie CalaisAhmanson Translational Theranostics Division, UCLA, Los Angeles, California.

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
MELT: Modulation of PSMA Expression for Lutetium TherapyR01CA235741 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOPE, THOMAS A · 2019 to 2025
$3.2M
Qualification and Harmonization of PET/MRI for Cancer Clinical TrialsR01CA212148 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOPE, THOMAS, LAFOREST, RICHARD ANDRE · 2017 to 2022
$2.7M
NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA212148NCI NIH HHS R01 CA235741
6 · The paper itself

Abstract

Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy can improve the outcome of patients with advanced metastatic castration-resistant prostate cancer, but patients do not respond uniformly. We hypothesized that using the salivary glands as a reference organ can enable selective patient stratification. We aimed to establish a PSMA PET tumor-to-salivary gland ratio (PSG score) to predict outcomes after [

Indexed as

Prostate-Specific AntigenProstatic Neoplasms, Castration-ResistantDipeptidesGallium RadioisotopesHeterocyclic Compounds, 1-RingHumansLutetiumMaleRadiopharmaceuticalsReproducibility of ResultsRetrospective StudiesSalivary GlandsTreatment OutcomeDipeptidesGallium RadioisotopesHeterocyclic Compounds, 1-RingLutetiumProstate-Specific AntigenRadiopharmaceuticals[177Lu]PSMAparotid glandsPSMA PETradioligand therapyvisual criteria

Identifiers

PMID36997329
PMCPMC11937727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.