Evidence map›Paper›PMID 36997323›Full record

ArticleNeurology2023

Altered Gaze Control During Emotional Face Exploration in Patients With Amyotrophic Lateral Sclerosis.

Felix Nanning, Katharina Braune, Ingo Uttner, Albert Christian Ludolph, Martin Gorges, Dorothée Lulé

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Felix NanningFrom the Department of Neurology (F.N., K.B., I.U., A.C.L., D.L.), University of Ulm; German Center for Neurodegenerative Diseases (DZNE) (A.C.L.), Ulm; and Institute of Medical Technology (M.G.), Brandenburg University of Technology, Cottbus-Senftenberg, Germany.
Katharina BrauneFrom the Department of Neurology (F.N., K.B., I.U., A.C.L., D.L.), University of Ulm; German Center for Neurodegenerative Diseases (DZNE) (A.C.L.), Ulm; and Institute of Medical Technology (M.G.), Brandenburg University of Technology, Cottbus-Senftenberg, Germany.
Ingo UttnerFrom the Department of Neurology (F.N., K.B., I.U., A.C.L., D.L.), University of Ulm; German Center for Neurodegenerative Diseases (DZNE) (A.C.L.), Ulm; and Institute of Medical Technology (M.G.), Brandenburg University of Technology, Cottbus-Senftenberg, Germany.
Albert Christian LudolphFrom the Department of Neurology (F.N., K.B., I.U., A.C.L., D.L.), University of Ulm; German Center for Neurodegenerative Diseases (DZNE) (A.C.L.), Ulm; and Institute of Medical Technology (M.G.), Brandenburg University of Technology, Cottbus-Senftenberg, Germany.
Martin GorgesFrom the Department of Neurology (F.N., K.B., I.U., A.C.L., D.L.), University of Ulm; German Center for Neurodegenerative Diseases (DZNE) (A.C.L.), Ulm; and Institute of Medical Technology (M.G.), Brandenburg University of Technology, Cottbus-Senftenberg, Germany.
Dorothée LuléFrom the Department of Neurology (F.N., K.B., I.U., A.C.L., D.L.), University of Ulm; German Center for Neurodegenerative Diseases (DZNE) (A.C.L.), Ulm; and Institute of Medical Technology (M.G.), Brandenburg University of Technology, Cottbus-Senftenberg, Germany. dorothee.lule@uni-ulm.de.
German Center for Neurodegenerative Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesUp to 50% of patients with amyotrophic lateral sclerosis (ALS) present with cognitive problems and behavioral dysfunctions including recognition of human faces presenting different emotions. We investigated whether impaired processing of emotional faces is associated with abnormal scan paths during visual exploration.

methodsCognitively unimpaired patients with ALS (n = 45) and matched healthy controls (n = 37) underwent neuropsychological assessment and video-based eye tracking. Eye movements were recorded while participants visually explored faces expressing different emotions (neutral, disgusted, happy, fearful, and sad) and houses mimicking faces.

resultsCompared with controls, patients with ALS fixated significantly longer to regions which are not relevant for emotional information when faces expressed fear ( DISCUSSION: In cognitively unimpaired patients with ALS, altered gaze patterns while visually exploring faces expressing different emotions might derive from impaired top-down attentional control with possible involvement of subliminal frontotemporal areas. This may account for indistinctness in emotion recognition reported in previous studies because nonsalient features retrieve more attention compared with salient areas. Current findings may indicate distinct emotion processing dysfunction of ALS pathology, which may be different from, for example, executive dysfunction.

Indexed as

Amyotrophic Lateral SclerosisEmotionsEyeEye MovementsFacial ExpressionHumansRecognition, Psychology

Identifiers

PMID36997323
PMCPMC10424840
OpenAlexW4361250559

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.