Evidence map›Paper›PMID 36997315›Full record

ReviewJournal of neurology, neurosurgery, and psychiatry2023

Advances in diagnosis and management of distal sensory polyneuropathies.

Matthew Silsby, Eva L Feldman, Richard D Dortch, Alison Roth, Simon Haroutounian, Yusuf A Rajabally, Steve Vucic, Michael E Shy, Anne Louise Oaklander, Neil G Simon

Open access · greenAbstract readReview
In one paragraph

Review in Journal of neurology, neurosurgery, and psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 4 countries.

Matthew SilsbyNeurology, Westmead Hospital, Westmead, New South Wales, Australia.ORCID 0000-0002-7249-210X
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Richard D DortchDivision of Neuroimaging Research, Barrow Neurological Institute, Phoenix, Arizona, USA.
Alison RothDivision of Neuroimaging Research, Barrow Neurological Institute, Phoenix, Arizona, USA.
Simon HaroutounianDepartment of Anesthesiology, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA.
Yusuf A RajaballyInflammatory Neuropathy Clinic, Department of Neurology, University Hospitals Birmingham, Aston Medical School, Aston University, Birmingham, UK.ORCID 0000-0002-7170-8343
Steve VucicBrain and Nerve Research Centre, Sydney Medical School, The University of Sydney, New South Wales, Australia.ORCID 0000-0002-8323-873X
Michael E ShyDepartment of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Anne Louise OaklanderNerve Unit, Departments of Neurology and Pathology (Neuropathology), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9578-1596
Neil G SimonNorthern Beaches Clinical School, Macquarie University, Frenchs Forest, New South Wales, Australia neil@nbneuro.com.au.ORCID 0000-0003-1784-8238
Barrow Neurological Institute · USThe University of Sydney · AUAston University · GBBaptist Medical Center Beaches · USHarvard University · USUniversity of Iowa · USUniversity of Michigan · USWashington University in St. Louis · US

Funding

trainingU54NS065712 · NINDS · WAYNE STATE UNIVERSITY · PI ZUCHNER, STEPHAN · 2009 to 2023
$19.6M
Integrated Systems Biology Approach to Diabetic Microvascular ComplicationsR24DK082841 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABCOUWER, STEVEN F, BROSIUS, FRANK C · 2008 to 2020
$13.1M
Evaluation of Small-Fiber Polyneuropathy in YouthR01NS093653 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI OAKLANDER, ANNE LOUISE · 2015 to 2024
$7.2M
Schwann Cell Senescence and the Secretome Provide a Unifying Mechanism for the Onset and Progression of Diabetic NeuropathyR01DK130913 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eva Lucille Feldman, Junguk Hur · 2022 to 2026
$3.3M
Genomic Studies in Charcot-Marie-Tooth DiseaseR01NS105755 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHY, MICHAEL E., ZUCHNER, STEPHAN · 2019 to 2023
$3.2M
5-HT3 receptor antagonists for neuropathic painR01NS104500 · NINDS · WASHINGTON UNIVERSITY · PI HAROUTOUNIAN, SIMON · 2018 to 2022
$2.2M
MRI Biomarkers of Disease Progression in Inherited NeuropathiesR21TR003312 · NCATS · WAYNE STATE UNIVERSITY · PI DORTCH, RICHARD, LI, JUN · 2021 to 2022
$440k
NCATS NIH HHS R21 TR003312NIDDK NIH HHS R01 DK130913NIDDK NIH HHS R24 DK082841NINDS NIH HHS R01 NS093653NINDS NIH HHS R01 NS104500NINDS NIH HHS R01 NS105755NINDS NIH HHS U54 NS065712
6 · The paper itself

Abstract

Distal sensory polyneuropathy (DSP) is characterised by length-dependent, sensory-predominant symptoms and signs, including potentially disabling symmetric chronic pain, tingling and poor balance. Some patients also have or develop dysautonomia or motor involvement depending on whether large myelinated or small fibres are predominantly affected. Although highly prevalent, diagnosis and management can be challenging. While classic diabetes and toxic causes are well-recognised, there are increasingly diverse associations, including with dysimmune, rheumatological and neurodegenerative conditions. Approximately half of cases are initially considered idiopathic despite thorough evaluation, but often, the causes emerge later as new symptoms develop or testing advances, for instance with genetic approaches. Improving and standardising DSP metrics, as already accomplished for motor neuropathies, would permit in-clinic longitudinal tracking of natural history and treatment responses. Standardising phenotyping could advance research and facilitate trials of potential therapies, which lag so far. This review updates on recent advances and summarises current evidence for specific treatments.

Indexed as

PolyneuropathiesHumansNEUROGENETICSNEUROIMMUNOLOGYNEUROMUSCULARNEUROPATHYPERIPHERAL NEUROPATHOLOGY

Identifiers

PMID36997315
PMCPMC10544692
OpenAlexW4361268774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.