Evidence map›Paper›PMID 36997252›Full record

ArticleBMJ open2023

Efficacy of mecobalamin (vitamin B

Karin Sall Hansson, Gunilla Lindqvist, Kent Stening, Jan Fohlman, Anna Wojanowski, Moa Ponten, Karin Jensen, Björn Gerdle, Carina Elmqvist

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05008042 (Evaluation of the Efficiacy of Mecobalamine), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05008042 phase1 / phase2completednot on this map

Evaluation of the Efficiacy of Mecobalamine (Vit B12) in the Treatment of Long-term Pain in Women Diagnosed With Fibromyalgia: Single-blind Randomized Controlled Trial With Three-month Follow up

TypeinterventionalSponsorLinnaeus UniversityRan2019 to 2024Enrolled40ConditionsFibromyalgiaArmsMecobalamin 5 MG, Placebo Comparator : NaCl 9 mg/ml
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Karin Sall HanssonDepartment of Health and Caring Sciences, Linnaeus University, Linnaeus University Faculty of Health and Life Sciences, Växjö, Sweden.
Gunilla LindqvistDepartment of Health and Caring Sciences, Linnaeus University, Linnaeus University Faculty of Health and Life Sciences, Växjö, Sweden.
Kent SteningDepartment of Health and Caring Sciences, Linnaeus University, Linnaeus University Faculty of Health and Life Sciences, Växjö, Sweden.
Jan FohlmanDepartment of Research and development, Region Kronoberg, Vaxjo, Sweden.
Anna WojanowskiDepartment of Research and development, Region Kronoberg, Vaxjo, Sweden.
Moa PontenThe Pain Neuroimagine Lab, Karolinska Institute, Stockholm, Sweden.
Karin JensenThe Pain Neuroimagine Lab, Karolinska Institute, Stockholm, Sweden.
Björn GerdlePain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linkopings Universitet, Linkoping, Sweden.
Carina ElmqvistDepartment of Health and Caring Sciences, Linnaeus University, Linnaeus University Faculty of Health and Life Sciences, Växjö, Sweden carina.elmqvist@lnu.se.ORCID 0000-0001-8376-8805
Linnaeus University · SEAlstom (Sweden) · SEKarolinska Institutet · SELinköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFibromyalgia causes long-term pain. It affects at least 2% of the population, the majority being women. In addition, extended symptoms corresponding to vitamin B METHODS AND ANALYSIS: The study is a randomised, placebo-controlled, single-blind, clinical trial with two parallel groups which are administered mecobalamin (vitamin B ETHICS AND DISSEMINATION: The protocol for the study is approved by the local ethical committee at Linkoping (EPM; 2018/294-31, appendices 2019-00347 and 2020-04482). The principles of the Helsinki Declaration are followed regarding oral and written consent to participate, confidentiality and the possibility to withdraw participation from the study at any time. The results will primarily be communicated through peer-reviewed journals and conferences. TRIAL REGISTRATION NUMBER: NCT05008042.

Indexed as

FibromyalgiaDouble-Blind MethodFemaleHumansPainRandomized Controlled Trials as TopicSingle-Blind MethodTreatment OutcomeVitamin B 12VitaminsmecobalaminVitamin B 12VitaminsClinical trialsCOMPLEMENTARY MEDICINEPAIN MANAGEMENTQUALITATIVE RESEARCHSTATISTICS & RESEARCH METHODS

Identifiers

PMID36997252
PMCPMC10069488
OpenAlexW4362522997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.