Evidence map›Paper›PMID 36997136›Full record

ArticleNeuroImage2023

Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men.

Michele Deantoni, Marion Baillet, Gregory Hammad, Christian Berthomier, Mathilde Reyt, Mathieu Jaspar, Christelle Meyer, Maxime Van Egroo, Puneet Talwar, Eric Lambot and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 5 countries.

Michele DeantoniGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Marion BailletGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Gregory HammadGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Christian BerthomierPhysip, Paris, France.
Mathilde ReytGIGA-CRC in Vivo Imaging, University of Liège, Belgium; Psychology and Neurosciences of Cognition (PsyNCog), Faculty of Psychology, Logopedics and Educational Sciences University of Liège, Belgium.
Mathieu JasparARCH, Faculty of Psychology, Logopedics and Educational Sciences, University of Liège, Belgium.
Christelle MeyerGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Maxime Van EgrooFaculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands.
Puneet TalwarGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Eric LambotGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Sarah L ChellappaDepartment of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany.
Christian DegueldreGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
André LuxenGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Eric SalmonGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Evelyne BalteauGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Christophe PhillipsGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Derk-Jan DijkSleep Research Centre, University of Surrey, Guildford, UK; UK Dementia Research Institute, Care Research & Technology Centre at Imperial College London and the University of Surrey, Guildford, UK.
Gilles VandewalleGIGA-CRC in Vivo Imaging, University of Liège, Belgium.
Fabienne ColletteGIGA-CRC in Vivo Imaging, University of Liège, Belgium; Psychology and Neurosciences of Cognition (PsyNCog), Faculty of Psychology, Logopedics and Educational Sciences University of Liège, Belgium.
Pierre MaquetGIGA-CRC in Vivo Imaging, University of Liège, Belgium; Department of Neurology, University Hospital (CHU) of Liège, Liège, Belgium.
Vincenzo MutoGIGA-CRC in Vivo Imaging, University of Liège, Belgium. Electronic address: vincenzo.muto@uliege.be.
Christina SchmidtGIGA-CRC in Vivo Imaging, University of Liège, Belgium; Psychology and Neurosciences of Cognition (PsyNCog), Faculty of Psychology, Logopedics and Educational Sciences University of Liège, Belgium. Electronic address: christina.schmidt@uliege.be.
University of Liège · BECollège de Physique et de Philosophie · FRImperial College London · GBMaastricht University · NLUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep has been suggested to contribute to myelinogenesis and associated structural changes in the brain. As a principal hallmark of sleep, slow-wave activity (SWA) is homeostatically regulated but also differs between individuals. Besides its homeostatic function, SWA topography is suggested to reflect processes of brain maturation. Here, we assessed whether interindividual differences in sleep SWA and its homeostatic response to sleep manipulations are associated with in-vivo myelin estimates in a sample of healthy young men. Two hundred twenty-six participants (18-31 y.) underwent an in-lab protocol in which SWA was assessed at baseline (BAS), after sleep deprivation (high homeostatic sleep pressure, HSP) and after sleep saturation (low homeostatic sleep pressure, LSP). Early-night frontal SWA, the frontal-occipital SWA ratio, as well as the overnight exponential SWA decay were computed over sleep conditions. Semi-quantitative magnetization transfer saturation maps (MTsat), providing markers for myelin content, were acquired during a separate laboratory visit. Early-night frontal SWA was negatively associated with regional myelin estimates in the temporal portion of the inferior longitudinal fasciculus. By contrast, neither the responsiveness of SWA to sleep saturation or deprivation, its overnight dynamics, nor the frontal/occipital SWA ratio were associated with brain structural indices. Our results indicate that frontal SWA generation tracks inter-individual differences in continued structural brain re-organization during early adulthood. This stage of life is not only characterized by ongoing region-specific changes in myelin content, but also by a sharp decrease and a shift towards frontal predominance in SWA generation.

Indexed as

ElectroencephalographyMyelin SheathAdultBrainHumansMaleSleepSleep DeprivationMyelin markerssemi-quantitative MRISleep homeostasisSleep slow-wave activity

Identifiers

PMID36997136
PMCPMC10112274
OpenAlexW4361285261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.