ArticleNature2023
Adeno-associated virus 2 infection in children with non-A-E hepatitis.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 4 pooled it
29.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 4 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- British Society of Gastroenterology guidelines for diagnosis and management of autoimmune hepatitis.Gut · 2025Guideline
- Current Trends of Human Adenovirus Types Among Hospitalized Children-A Systematic Review.Viruses · 2025Pooled it
- A systematic review of immunosuppressive protocols used in AAV gene therapy for monogenic disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Pooled it
- Pooled it
- Host Endoplasmic Reticulum Stress and Interferon Responses Contribute to AAV-Induced Ocular Toxicity.bioRxiv : the preprint server for biology · 2026Article
- Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF).Hepatology communications · 2026Review
- Adeno-Associated Virus Type 2 and Human Adenovirus Species F Type 41 Co-infection Associated with Acute Severe Hepatitis in Children, California, USA.Emerging infectious diseases · 2026Article
- Empowering One Health with metagenomics.One health outlook · 2026Review
- Seroprevalence of anti-AAV neutralizing antibodiesin healthy and retinitis pigmentosa cohorts: A multi-province study in China.Molecular therapy. Advances · 2026Article
- Traveling with chronic viral hepatitis.Tropical diseases, travel medicine and vaccines · 2026Review
- GGT-Normal Cholestasis in an Older Child: A Suspected Case of Benign Recurrent Intrahepatic Cholestasis From Syria.Clinical case reports · 2026Article
- Virus-Dependent Geographic Structure of Co-Circulating Viruses in a Single Bat Species.Molecular ecology · 2026Article
- Contaminating plasmid sequences and disrupted vector genomes in the liver following adeno-associated virus gene therapy.Nature medicine · 2026Article
- AAV2-associated liver injury across infection and gene therapy: converging genomic signals.Frontiers in immunology · 2026Article
- Clinical metagenomics for diagnosis and surveillance of viral pathogens.Nature reviews. Microbiology · 2026Review
- Respiratory virus genomic epidemiology during post-pandemic re-emergence of influenza in Australia.Virus evolution · 2026Article
- Review
- Comparison of three pediatric studies investigating acute hepatitis of unknown etiology.World journal of virology · 2025Review
- Review
- Efficient Scaling up EV-AAVs Production via Cellular Nanoporation for Familial Hypercholesterolaemia Therapy.Journal of extracellular vesicles · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
58 authors at 20 institutions in 16 countries.
Antonia Ho *Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Richard Orton *Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Rachel Tayler *Department of Paediatrics, Royal Hospital for Children, Glasgow, UK.
Patawee Asamaphan *Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Vanessa Herder *Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Chris Davis *Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Lily TongMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.ORCID 0000-0003-3882-3339
Katherine SmollettMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Maria ManaliMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Jay AllanMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Konrad RawlikPandemic Science Hub, Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-0010-370X
Sarah E McDonaldMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.ORCID 0000-0003-2776-7415
Elen VinkMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.ORCID 0000-0001-8535-6214
Louisa PollockMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Louise GannonDepartment of Paediatrics, NHS Tayside, Dundee, UK.
Clair EvansDepartment of Pathology, Queen Elizabeth University Hospital, Glasgow, UK.
Jim McMenaminPublic Health Scotland, Glasgow, UK.
Kirsty RoyPublic Health Scotland, Glasgow, UK.
Kimberly MarshPublic Health Scotland, Glasgow, UK.
Titus DivalaPublic Health Scotland, Glasgow, UK.ORCID 0000-0003-3029-9579
Matthew T G HoldenPublic Health Scotland, Glasgow, UK.
Michael LockhartPublic Health Scotland, Glasgow, UK.
David YirrellPublic Health Scotland, Glasgow, UK.
Sandra CurriePublic Health Scotland, Glasgow, UK.
Maureen O'LearyPublic Health Scotland, Glasgow, UK.ORCID 0000-0001-6797-9282
David HendersonPublic Health Scotland, Glasgow, UK.
Samantha J ShepherdWest of Scotland Specialist Virology Centre, Glasgow, UK.
Celia JacksonWest of Scotland Specialist Virology Centre, Glasgow, UK.
Rory GunsonWest of Scotland Specialist Virology Centre, Glasgow, UK.
Alasdair MacLeanWest of Scotland Specialist Virology Centre, Glasgow, UK.
Neil McInnesWest of Scotland Specialist Virology Centre, Glasgow, UK.
Amanda Bradley-StewartVirology Laboratory, Ninewells Hospital, Dundee, UK.
Richard BattleHistocompatibility and Immunogenetics (H&I) Laboratory, Scottish National Blood Transfusion Service, Edinburgh Royal Infirmary, Edinburgh, UK.
Jill A HollenbachDepartment of Neurology and Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Paul HendersonChild Life and Health, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-3634-6428
Miranda OdamPandemic Science Hub, Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK.
Primrose ChikoworePandemic Science Hub, Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK.
Wilna OosthuyzenPandemic Science Hub, Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK.
Meera ChandUK Health Security Agency, London, UK.
Melissa Shea HamiltonSection of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London, UK.
Diego Estrada-RivadeneyraSection of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London, UK.ORCID 0000-0003-2512-7131
Michael LevinSection of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, London, UK.ORCID 0000-0003-2767-6919
Nikos AvramidisPandemic Science Hub, Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK.
Erola Pairo-CastineiraPandemic Science Hub, Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK.
Veronique VitartPandemic Science Hub, Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK.
Craig WilkieSchool of Mathematics and Statistics, University of Glasgow, Glasgow, UK.ORCID 0000-0003-0805-0195
DIAMONDS Consortium
ISARIC4C Investigators
Massimo PalmariniMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.ORCID 0000-0001-7007-4070
Surajit RaySchool of Mathematics and Statistics, University of Glasgow, Glasgow, UK.ORCID 0000-0003-3965-8136
David L RobertsonMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.ORCID 0000-0001-6338-0221
Ana da Silva FilipeMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.
Brian J WillettMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.ORCID 0000-0001-8912-3266
Judith BreuerUniversity College London, London, UK.ORCID 0000-0001-8246-0534
Malcolm G SemplePandemic Institute, University of Liverpool, Liverpool, UK.ORCID 0000-0001-9700-0418
David TurnerHistocompatibility and Immunogenetics (H&I) Laboratory, Scottish National Blood Transfusion Service, Edinburgh Royal Infirmary, Edinburgh, UK.ORCID 0000-0003-4007-6248
J Kenneth BailliePandemic Science Hub, Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-5258-793X
Emma C ThomsonMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK. emma.thomson@glasgow.ac.uk.ORCID 0000-0003-1482-0889
Imperial College London · GBMedical University of Graz · ATUniversidade de Santiago de Compostela · ESUniversity of Liverpool · GBHôpital Louis-Mourier · FRMRC University of Glasgow Centre for Virus Research · GBRoslin Institute · GBUniversity of Edinburgh · GBUniversity of Bern · CHEmma Kinderziekenhuis · NLLjubljana University Medical Centre · SILudwig-Maximilians-Universität München · DEPublic Health Scotland · GBCoventry (United Kingdom) · GBHospital Universitario 12 De Octubre · ESJohn Radcliffe Hospital · GBLondon School of Hygiene & Tropical Medicine · GBNational and Kapodistrian University of Athens · GRNewcastle upon Tyne Hospitals NHS Foundation Trust · GBRoyal Hospital for Children · GB
Funding
MHC Variation in Host Response to SARS-CoV2 and COVID-19 OutcomesR01AI159260 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLENBACH, JILL ALLISON · 2021 to 2025
$4.0MThe landscape of HLA mediated variation in health and immunityR01AI158861 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLENBACH, JILL ALLISON · 2021 to 2025
$3.5MDepartment of Health CO-CIN-01Medical Research Council MC_PC_19025Medical Research Council MC_PC_19059Medical Research Council MC_PC_20029Medical Research Council MC_PC_22004Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00034/5Medical Research Council MC_UU_00034/6Medical Research Council MC_UU_12014/1Medical Research Council MC_UU_12014/12Medical Research Council MR/W005611/1Medical Research Council MR/W030454/1Medical Research Council MR/X010252/1NIAID NIH HHS R01 AI158861NIAID NIH HHS R01 AI159260Wellcome Trust 206369Wellcome Trust 206369/Z/17/ZWellcome Trust 223164
Abstract
An outbreak of acute hepatitis of unknown aetiology in children was reported in Scotland
Indexed as
Adenovirus Infections, HumanDependovirusHepatitisAcute DiseaseAllelesCase-Control StudiesCD4-Positive T-LymphocytesChildCoinfectionGenetic Predisposition to DiseaseHelper VirusesHepatocytesHLA-DRB1 ChainsHumansLiverHLA-DRB1 Chains
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.