ArticleNature2023
Genomic investigations of unexplained acute hepatitis in children.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
24.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Current Trends of Human Adenovirus Types Among Hospitalized Children-A Systematic Review.Viruses · 2025Pooled it
- A systematic review of immunosuppressive protocols used in AAV gene therapy for monogenic disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Pooled it
- Host Endoplasmic Reticulum Stress and Interferon Responses Contribute to AAV-Induced Ocular Toxicity.bioRxiv : the preprint server for biology · 2026Article
- Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF).Hepatology communications · 2026Review
- Whole-genome sequencing of adenovirus 41 directly from wastewater using nested overlapping PCR and MinION.Microbiology spectrum · 2026Article
- Adeno-Associated Virus Type 2 and Human Adenovirus Species F Type 41 Co-infection Associated with Acute Severe Hepatitis in Children, California, USA.Emerging infectious diseases · 2026Article
- Article
- Seroprevalence of anti-AAV neutralizing antibodiesin healthy and retinitis pigmentosa cohorts: A multi-province study in China.Molecular therapy. Advances · 2026Article
- One health viral metagenomics for pathogen surveillance: robust mNGS workflows for viral detection and genome recovery from swab and tissue specimens.BMC microbiology · 2026Article
- Contaminating plasmid sequences and disrupted vector genomes in the liver following adeno-associated virus gene therapy.Nature medicine · 2026Article
- Clinical metagenomics for diagnosis and surveillance of viral pathogens.Nature reviews. Microbiology · 2026Review
- Editorial: New discoveries and challenges in pediatric infectious diseases: epidemiological, clinical, and pathogenic advances.Frontiers in pediatrics · 2026Article
- AAV2-associated liver injury across infection and gene therapy: converging genomic signals.Frontiers in immunology · 2026Article
- Viral diversity influences T-cell responses to enteric human adenoviruses F40 and F41.Virus evolution · 2026Article
- Review
- Comparison of three pediatric studies investigating acute hepatitis of unknown etiology.World journal of virology · 2025Review
- Genomic Epidemiological Characteristics of Enteric Adenovirus F40 and F41 in Yantai, China, from 2022 to 2023.Viruses · 2025Article
- No apparent increase in cases of severe acute hepatitis of unknown etiology with fulminant liver failure in children in Germany, 2022.JPGN reports · 2025Article
- Article
- Severe hepatitis in pediatric patients: The Severe Hepatitis In Pediatric Patients (SHIPP) registry.Journal of pediatric gastroenterology and nutrition · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
90 authors at 20 institutions in 18 countries.
Sofia Morfopoulou *Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Sarah Buddle *Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-4738-9469
Oscar Enrique Torres MontaguthInfection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Laura AtkinsonDepartment of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
José Afonso Guerra-AssunçãoInfection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0001-6593-403X
Mahdi Moradi MarjanehSection for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0002-9412-9029
Riccardo Zennezini ChiozziUniversity College London Mass Spectrometry Science Technology Platform, Division of Biosciences, University College London, London, UK.
Nathaniel StoreyDepartment of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID 0000-0001-5942-4674
Luis CamposHistopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID 0000-0002-4317-0013
J Ciaran HutchinsonHistopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
John R CounsellResearch Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK.ORCID 0000-0001-9208-101X
Gabriele PollaraDivision of Infection and Immunity, University College London, London, UK.ORCID 0000-0001-5772-0322
Sunando RoyInfection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Cristina VenturiniInfection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Juan F Antinao DiazResearch Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK.
Ala'a SiamResearch Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK.
Luke J TappouniResearch Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK.ORCID 0000-0003-2397-0512
Zeinab AsgarianResearch Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK.
Joanne NgGene Transfer Technology Group, EGA-Institute for Women's Health, University College London, London, UK.
Killian S HanlonResearch Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK.
Alexander LennonDepartment of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID 0000-0002-3363-0637
Andrew McArdleSection for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0001-7448-0869
Agata CzapDivision of Infection and Immunity, University College London, London, UK.
Joshua RosenheimDivision of Infection and Immunity, University College London, London, UK.ORCID 0000-0003-0171-2053
Catarina AndradeHistopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Glenn AndersonHistopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Jack C D LeeDepartment of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID 0000-0002-9866-2808
Rachel WilliamsGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Charlotte A WilliamsGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Helena TutillGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-9977-9012
Nadua BayzidGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Luz Marina Martin BernalGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Hannah MacphersonDepartment of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, UK.
Kylie-Ann MontgomeryGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Catherine MooreWales Specialist Virology Centre, Public Health Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK.ORCID 0000-0001-8934-0930
Kate TempletonDepartment of Medical Microbiology, Edinburgh Royal Infirmary, Edinburgh, UK.
Claire NeillPublic Health Agency Northern Ireland, Belfast, UK.
Matt HoldenSchool of Medicine, University of St. Andrews, St. Andrews, UK.
Rory GunsonWest of Scotland Specialist Virology Centre, Glasgow, UK.
Samantha J ShepherdWest of Scotland Specialist Virology Centre, Glasgow, UK.
Priyen ShahSection for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK.
Samantha CooraySection for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK.
Marie VoiceMicropathology Ltd, University of Warwick Science Park, Coventry, UK.
Michael SteeleMicropathology Ltd, University of Warwick Science Park, Coventry, UK.
Colin FinkMicropathology Ltd, University of Warwick Science Park, Coventry, UK.ORCID 0000-0002-8008-5870
Thomas E WhittakerMolecular and Cellular Immunology, Great Ormond Street Institute of Child Health, University College London, London, UK.
Giorgia SantilliMolecular and Cellular Immunology, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0003-1776-1984
Paul GissenGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-9712-6122
Benedikt B KauferInstitute of Virology, Freie Universität Berlin, Berlin, Germany.
Jana ReichInstitute of Virology, Freie Universität Berlin, Berlin, Germany.
Julien AndreaniNuffield Department of Medicine, University of Oxford, Oxford, UK.
Peter SimmondsNuffield Department of Medicine, University of Oxford, Oxford, UK.
Dimah K AlrabiahGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Sergi CastellanoGenetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Primrose ChikoworeRoslin Institute, University of Edinburgh, Edinburgh, UK.
Miranda OdamRoslin Institute, University of Edinburgh, Edinburgh, UK.
Tommy RamplingDivision of Infection and Immunity, University College London, London, UK.
Catherine HoulihanDivision of Infection and Immunity, University College London, London, UK.
Katja HoschlerUK Health Security Agency, London, UK.
Tiina TaltsUK Health Security Agency, London, UK.
Cristina CelmaUK Health Security Agency, London, UK.ORCID 0000-0003-2223-5057
Suam GonzalezUK Health Security Agency, London, UK.
Eileen GallagherUK Health Security Agency, London, UK.
Ruth SimmonsUK Health Security Agency, London, UK.
Conall WatsonUK Health Security Agency, London, UK.
Sema MandalUK Health Security Agency, London, UK.
Maria ZambonUK Health Security Agency, London, UK.
Meera ChandUK Health Security Agency, London, UK.
James HatcherDepartment of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Surjo DeDepartment of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Kenneth BaillieRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-5258-793X
Malcolm Gracie SemplePandemic Institute, University of Liverpool, Liverpool, UK.ORCID 0000-0001-9700-0418
DIAMONDS Consortium
PERFORM Consortium
ISARIC 4C Investigators
Joanne MartinCentre for Genomics and Child Health, The Blizard Institute, Queen Mary University of London, London, UK.
Ines Ushiro-LumbNHS Blood and Transplant, Bristol, UK.ORCID 0000-0003-0989-8091
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London, UK.ORCID 0000-0002-4774-0853
Maesha DeheragodaKing's College Hospital, London, UK.
Nedim HadzicKing's College Hospital, London, UK.
Tassos GrammatikopoulosKing's College Hospital, London, UK.
Rachel BrownDepartment of Cellular Pathology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Chayarani KelgeriLiver Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
Konstantinos ThalassinosUniversity College London Mass Spectrometry Science Technology Platform, Division of Biosciences, University College London, London, UK.ORCID 0000-0001-5072-8428
Simon N WaddingtonGene Transfer Technology Group, EGA-Institute for Women's Health, University College London, London, UK.ORCID 0000-0003-4970-4730
Thomas S JacquesHistopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Emma ThomsonMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK.ORCID 0000-0003-1482-0889
Michael LevinSection for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0003-2767-6919
Julianne R BrownDepartment of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Judith BreuerInfection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK. j.breuer@ucl.ac.uk.ORCID 0000-0001-8246-0534
Imperial College London · GBMedical University of Graz · ATNewcastle upon Tyne Hospitals NHS Foundation Trust · GBUniversidade de Santiago de Compostela · ESUniversity of Liverpool · GBLudwig-Maximilians-Universität München · DEGreat Ormond Street Hospital · GBChildren's Clinical University Hospital · LVUniversity of Amsterdam · NLGreat Ormond Street Hospital for Children NHS Foundation Trust · GBRadboud University Nijmegen · NLHôpital Louis-Mourier · FRUK Health Security Agency · GBLjubljana University Medical Centre · SILondon School of Hygiene & Tropical Medicine · GBNational and Kapodistrian University of Athens · GRUniversity of Edinburgh · GBMRC Unit the Gambia · GMCoventry (United Kingdom) · GBSanquin · NL
Funding
Medical Research Council MC_PC_19059Medical Research Council MC_UU_00034/6Medical Research Council MC_UU_12014/1Wellcome Trust 206478Wellcome Trust 206478/Z/17/Z
Abstract
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK
Indexed as
Adenovirus Infections, HumanGenomicsHepatitisAcute DiseaseB-LymphocytesChildDependovirusGene Expression ProfilingHumansImmunohistochemistryLiverProteomicsT-Lymphocytes
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.