ArticleNature2023
Adeno-associated virus type 2 in US children with acute severe hepatitis.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
35.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- A systematic review of immunosuppressive protocols used in AAV gene therapy for monogenic disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Pooled it
- Host Endoplasmic Reticulum Stress and Interferon Responses Contribute to AAV-Induced Ocular Toxicity.bioRxiv : the preprint server for biology · 2026Article
- Whole-genome sequencing of adenovirus 41 directly from wastewater using nested overlapping PCR and MinION.Microbiology spectrum · 2026Article
- Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF).Hepatology communications · 2026Review
- Drug combination treatment as a strategy for inhibiting human adenovirus replication.Antiviral research · 2026Article
- Distinct age-dependent phenotypes of abnormal liver function tests derived from national Emergency Department data.Clinical and experimental pediatrics · 2026Article
- Adeno-Associated Virus Type 2 and Human Adenovirus Species F Type 41 Co-infection Associated with Acute Severe Hepatitis in Children, California, USA.Emerging infectious diseases · 2026Article
- Seroprevalence of anti-AAV neutralizing antibodiesin healthy and retinitis pigmentosa cohorts: A multi-province study in China.Molecular therapy. Advances · 2026Article
- Respiratory virus genomic epidemiology during post-pandemic re-emergence of influenza in Australia.Virus evolution · 2026Article
- Clinical metagenomics for diagnosis and surveillance of viral pathogens.Nature reviews. Microbiology · 2026Review
- Review
- AAV2-associated liver injury across infection and gene therapy: converging genomic signals.Frontiers in immunology · 2026Article
- Comparison of three pediatric studies investigating acute hepatitis of unknown etiology.World journal of virology · 2025Review
- Review
- No apparent increase in cases of severe acute hepatitis of unknown etiology with fulminant liver failure in children in Germany, 2022.JPGN reports · 2025Article
- Human adenovirus in Taiwan, 2019-2023.Archives of virology · 2025Article
- Non hepatotropic virus induced hepatitis - rising importance in a changing world.World journal of virology · 2025Review
- Article
- Article
- Neutralizing Antibodies: Role in Immune Response and Viral Vector Based Gene Therapy.International journal of molecular sciences · 2025Review
Corrections and comments
- Commented on by
Authors and funding
49 authors at 15 institutions in 2 countries.
Venice Servellita *Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Alicia Sotomayor Gonzalez *Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8930-745X
Daryl M Lamson *Wadsworth Center, New York State Department of Health, David Axelrod Institute, Albany, NY, USA.
Abiodun ForesytheDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Hee Jae HuhDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Adam L BazinetNational Biodefense Analysis and Countermeasures Center (NBACC), Frederick, MD, USA.ORCID 0000-0002-9152-5923
Nicholas H BergmanNational Biodefense Analysis and Countermeasures Center (NBACC), Frederick, MD, USA.
Robert L BullFederal Bureau of Investigation Laboratory Division/Scientific Response and Analysis Unit, Quantico, VA, USA.
Karla Y GarciaNational Biodefense Analysis and Countermeasures Center (NBACC), Frederick, MD, USA.
Jennifer S GoodrichNational Biodefense Analysis and Countermeasures Center (NBACC), Frederick, MD, USA.
Sean P LovettNational Biodefense Analysis and Countermeasures Center (NBACC), Frederick, MD, USA.
Kisha ParkerNational Biodefense Analysis and Countermeasures Center (NBACC), Frederick, MD, USA.
Diana RaduneNational Biodefense Analysis and Countermeasures Center (NBACC), Frederick, MD, USA.
April HatadaCalifornia Department of Public Health, Richmond, CA, USA.
Chao-Yang PanCalifornia Department of Public Health, Richmond, CA, USA.
Kyle RizzoCalifornia Department of Public Health, Richmond, CA, USA.
J Bradford BertumenCalifornia Department of Public Health, Richmond, CA, USA.
Christina MoralesCalifornia Department of Public Health, Richmond, CA, USA.
Paul E OluniyiDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jenny NguyenDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jessica TanDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Doug StrykeDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Rayah JaberFlorida Department of Health, Tallahassee, FL, USA.
Matthew T LeslieIllinois Department of Public Health, Chicago, IL, USA.
Zin LyonsNorth Carolina Department of Health and Human Services, Raleigh, NC, USA.
Hayden D HedmanCenters for Disease Control and Prevention, Atlanta, CA, USA.
Umesh ParasharCenters for Disease Control and Prevention, Atlanta, CA, USA.
Maureen SullivanAssociation for Public Health Laboratories, Silver Spring, MD, USA.
Kelly WroblewskiAssociation for Public Health Laboratories, Silver Spring, MD, USA.
M Steven ObersteCenters for Disease Control and Prevention, Atlanta, CA, USA.
Jacqueline E TateCenters for Disease Control and Prevention, Atlanta, CA, USA.
Julia M BakerCenters for Disease Control and Prevention, Atlanta, CA, USA.ORCID 0000-0001-7872-316X
David SugermanCenters for Disease Control and Prevention, Atlanta, CA, USA.
Caelin PottsCenters for Disease Control and Prevention, Atlanta, CA, USA.
Xiaoyan LuCenters for Disease Control and Prevention, Atlanta, CA, USA.
Preeti ChhabraCenters for Disease Control and Prevention, Atlanta, CA, USA.
Pediatric Hepatitis of Unknown Etiology Working Group
L Amanda IngramAlabama Department of Public Health, Montgomery, AL, USA.
Henry ShiauUniversity of Alabama at Birmingham, Birmingham, AL, USA.
William BrittUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Luz Helena Gutierrez SanchezUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Caroline CiricDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Christina A RostadDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Jan VinjéCenters for Disease Control and Prevention, Atlanta, CA, USA.
Hannah L KirkingCenters for Disease Control and Prevention, Atlanta, CA, USA.
Debra A WadfordCalifornia Department of Public Health, Richmond, CA, USA.ORCID 0000-0002-8630-427X
R Taylor RabornNational Biodefense Analysis and Countermeasures Center (NBACC), Frederick, MD, USA.ORCID 0000-0001-6249-8033
Kirsten St GeorgeWadsworth Center, New York State Department of Health, David Axelrod Institute, Albany, NY, USA.
Charles Y ChiuDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA. charles.chiu@ucsf.edu.ORCID 0000-0003-2915-2094
Centers for Disease Control and Prevention · USUniversity of California, San Francisco · USCalifornia Department of Public Health · USBaylor College of Medicine · USFlorida Department of Health · USNC Department of Health and Human Services · USAlabama Department of Public Health · USAssociation of Public Health Laboratories · USCincinnati Children's Hospital Medical Center · USEmory University · USNew York State Department of Health · USUniversity of Alabama at Birmingham · USFederal Bureau of Investigation · USIllinois Department of Public Health · USUniversity at Albany, State University of New York · US
Funding
Discovery and clinical validation of host biomarkers of disease severity and multi-system inflammatory syndrome in children (MIS-C) with Covid-19R33HD105618 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIU, CHARLES YEN, DE VLAMINCK, IWIJN · 2023 to 2023
$3.2MUncovering associations of variant infection with COVID-19 disease severity in childrenR61HD105618 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIU, CHARLES YEN, DE VLAMINCK, IWIJN · 2021 to 2022
$3.2MNCIRD CDC HHS U01 IP001150NICHD NIH HHS R33 HD105618NICHD NIH HHS R61 HD105618
Abstract
As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have been reported from 35 countries, including the USA
Indexed as
Adenovirus Infections, HumanCoinfectionDependovirusHepatitisAcute DiseaseChildEnterovirus A, HumanEpstein-Barr Virus InfectionsHelper VirusesHerpesvirus 4, HumanHerpesvirus 6, HumanHumans
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.