Evidence map›Paper›PMID 36996870›Full record

ArticleNature2023

Copper-catalysed enantioconvergent alkylation of oxygen nucleophiles.

Caiyou Chen, Gregory C Fu

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Enantioconvergent Chan-Evans-Lam C(spJournal of the American Chemical Society · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Catalytic Metalloradical System for Radical 1,6-C(spJournal of the American Chemical Society · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Caiyou ChenDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0001-7536-7139
Gregory C FuDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA. gcfu@caltech.edu.ORCID 0000-0002-0927-680X

Funding

Metal-Catalyzed Nucleophilic Substitution Reactions of Alkyl ElectrophilesR35GM145315 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GREGORY C FU · 2022 to 2026
$4.5M
PHOTOINDUCED, COPPER-CATALYZED SUBSTITUTION REACTIONS OF ALKYL ELECTROPHILES BY NITROGEN NUCLEOPHILESR01GM109194 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI FU, GREGORY C · 2014 to 2021
$3.7M
NIGMS NIH HHS R01 GM109194NIGMS NIH HHS R35 GM145315
6 · The paper itself

Abstract

Carbon-oxygen bonds are commonplace in organic molecules, including chiral bioactive compounds; therefore, the development of methods for their construction with simultaneous control of stereoselectivity is an important objective in synthesis. The Williamson ether synthesis, first reported in 1850

Indexed as

AlkylationCatalysisCopperOxygenCarbonCarbonCopperOxygen

Identifiers

PMID36996870
PMCPMC10986234

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.