Evidence map›Paper›PMID 36996841›Full record

ArticleBiofabrication2023

Self-assembled innervated vasculature-on-a-chip to study nociception.

Vardhman Kumar, David Kingsley, Sajeeshkumar Madhurakkat Perikamana, Pankaj Mogha, C Rory Goodwin, Shyni Varghese

Open access · hybridAbstract read
In one paragraph

Article in Biofabrication, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Decoding Pain: Next-Generation In Vitro Systems for Mechanistic Insights and Drug Discovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  5. Extensive Periosteal Injury During Fracture Induces Long-Term Pain in Mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  6. Article
  7. Review
  8. Vascular microphysiological systems.Current opinion in hematology · 2024
    Review
  9. UDP-6-glucose dehydrogenase in hormonally responsive breast cancers.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vardhman KumarDepartment of Biomedical Engineering, Duke University, Durham, NC, United States of America.
David KingsleyDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, United States of America.ORCID 0000-0001-7564-989X
Sajeeshkumar Madhurakkat PerikamanaDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, United States of America.
Pankaj MoghaDepartment of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, United States of America.ORCID 0000-0003-0144-0107
C Rory GoodwinDepartment of Neurosurgery, Spine Division, Duke University Medical Center, Durham, NC, United States of America.
Shyni VargheseDepartment of Biomedical Engineering, Duke University, Durham, NC, United States of America.ORCID 0000-0002-0004-7947
Duke University · US

Funding

Modulation of local adenosine signaling to attenuate fracture painR01AR079189 · NIAMS · DUKE UNIVERSITY · PI VARGHESE, SHYNI · 2021 to 2025
$2.8M
NIAMS NIH HHS R01 AR079189
6 · The paper itself

Abstract

Nociceptor sensory neurons play a key role in eliciting pain. An active crosstalk between nociceptor neurons and the vascular system at the molecular and cellular level is required to sense and respond to noxious stimuli. Besides nociception, interaction between nociceptor neurons and vasculature also contributes to neurogenesis and angiogenesis.

Indexed as

Endothelial CellsNociceptionGanglia, SpinalHumansLab-On-A-Chip DevicesPainSensory Receptor Cellsinnervationorgan-on-a-chiptissue engineeringvascular tissue engineering

Identifiers

PMID36996841
PMCPMC10152403
OpenAlexW4361264527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.