ArticleImmunity2023
Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8
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Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69citing papers in PubMed
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Who cites it
69 citing papers in PubMed, 79 citations in OpenAlex.
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- The challenge and promise of studying human antigen-specific T cells.Nature reviews. Immunology · 2026Review
- Comprehensive longitudinal profiling identifies differential frequency, epitope specificity, and effector function of CD8EBioMedicine · 2026Article
- IL-10, IL-17A, and IFN-γ as clinical early-warning indicators for severe Epstein-Barr virus-associated infectious mononucleosis in children.BMC pediatrics · 2026Article
- Identification of immunodominant T cell epitopes in SARS-CoV-2 spike protein in Syrian hamsters.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
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- Conformational bias in SARS-CoV-2 Spike CD4+ T-cell epitope dominance.Frontiers in immunology · 2026Article
- Immunology of RNA-based vaccines: The critical interplay between inflammation and expression.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Persistent Classical and Atypical Memory B Cells Underlie Heterogeneous Vaccine Responses in Ocrelizumab-Treated Multiple Sclerosis.bioRxiv : the preprint server for biology · 2025Article
- Long-term impact of COVID-19 in patients with lung cancer receiving immune checkpoint inhibitors: a multicenter cohort study during Omicron pandemic.BMC infectious diseases · 2025Article
- Regulatory KIRScience translational medicine · 2025Article
- Clinical characteristics of optic neuritis following COVID-19 during Omicron outbreak in China.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Observational
- Narrowing Down Key Players in Autoimmunity via Single-Cell Multiomics.European journal of immunology · 2025Review
- Longitudinal Immunoprofiling of the CD8Vaccines · 2025Article
- LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment.Nature communications · 2025Article
- The Role of Memory T-Cell Mediated Immunity in Long-term COVID-19: Effects of Vaccination Status.Iranian journal of medical sciences · 2025Review
- Aging and inflammation limit the induction of SARS-CoV-2-specific CD8+ T cell responses in severe COVID-19.JCI insight · 2025Article
- Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 4 institutions in 1 country.
Fei GaoInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Vamsee MallajosyulaInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Prabhu S ArunachalamInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Kattria van der PloegDepartment of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.
Monali ManoharSean N. Parker Center for Allergy and Asthma Research, Stanford University and Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Katharina RöltgenDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Fan YangDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Oliver WirzDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Ramona HohDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Emily HaraguchiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Ji-Yeun LeeDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Richard WillisEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Vasanthi RamachandiranEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Jiefu LiInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Karan Raj KathuriaInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Chunfeng LiInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Alexandra S LeeSean N. Parker Center for Allergy and Asthma Research, Stanford University and Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Mihir M ShahSean N. Parker Center for Allergy and Asthma Research, Stanford University and Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Sayantani B SindherSean N. Parker Center for Allergy and Asthma Research, Stanford University and Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Joseph GonzalezDepartment of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
John D AltmanEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Taia T WangDepartment of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Scott D BoydSean N. Parker Center for Allergy and Asthma Research, Stanford University and Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Bali PulendranInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Prasanna JagannathanDepartment of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Kari C NadeauInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA; Sean N. Parker Center for Allergy and Asthma Research, Stanford University and Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard, MA, USA.
Mark M DavisInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. Electronic address: mmdavis@stanford.edu.
Stanford University · USEmory University · USHarvard University · USHoward Hughes Medical Institute · US
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MThe effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8MSystems biological assessment of T cell responses to vaccinationU19AI167903 · NIAID · STANFORD UNIVERSITY · PI BALI PULENDRAN · 2022 to 2026
$13.2MComputational models of naturally acquired immunity to falciparum malariaU01AI150741 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUTTE, ATUL J, GREENHOUSE, BRYAN R · 2020 to 2024
$7.4MT Cell Reagent Research for Monitoring T Cell in Food AllergyU01AI140498 · NIAID · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2018 to 2022
$1.8MHoward Hughes Medical InstituteNIAID NIH HHS P01 AI153559NIAID NIH HHS U01 AI140498NIAID NIH HHS U01 AI150741NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI167903
Abstract
T cells are a critical component of the response to SARS-CoV-2, but their kinetics after infection and vaccination are insufficiently understood. Using "spheromer" peptide-MHC multimer reagents, we analyzed healthy subjects receiving two doses of the Pfizer/BioNTech BNT162b2 vaccine. Vaccination resulted in robust spike-specific T cell responses for the dominant CD4
Indexed as
COVID-19VaccinesAntibodies, ViralBNT162 VaccineCD8-Positive T-LymphocytesHumansSARS-CoV-2VaccinationAntibodies, ViralBNT162 VaccineVaccinesantigen-specific T cell responsesCOVID-19peptide-MHC multimerperipheral CD4(+) T cell responsesperipheral CD8(+) T cell responsesPfizer/BioNTech mRNA vaccineSARS-CoV-2SARS-CoV-2 variants of concernspheromer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.