Evidence map›Paper›PMID 36996347›Full record

ArticleAmerican journal of respiratory and critical care medicine2023

Efficacy and Safety of Gefapixant for Refractory or Unexplained Chronic Cough over 52 Weeks.

Surinder S Birring, Peter V Dicpinigaitis, Jaclyn A Smith, Alyn H Morice, Lorcan P McGarvey, Ian D Pavord, Allison Martin Nguyen, Jonathan Schelfhout, Qing Li, Beata Iskold and 4 more

Abstract readLetter
In one paragraph

Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Gefapixant as a P2X3 receptor antagonist treatment for obstructive sleep apnea: a randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Trial
  5. Review
  6. Review
  7. Article
  8. Cough in idiopathic pulmonary fibrosis: what is new.Breathe (Sheffield, England) · 2025
    Article
  9. Review
  10. Article
  11. Reply to Weinberger.American journal of respiratory and critical care medicine · 2023
    Article
  12. What the Placebo Tells Us about Chronic Cough.American journal of respiratory and critical care medicine · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Surinder S BirringCentre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.ORCID 0000-0003-2525-6291
Peter V DicpinigaitisAlbert Einstein College of Medicine & Montefiore Medical Center, Bronx, New York.
Jaclyn A SmithDivision of Immunology, Immunity to Infection & Respiratory Medicine, University of Manchester and Manchester University National Health Service Trust, Manchester, United Kingdom.ORCID 0000-0001-8837-4928
Alyn H MoriceHull York Medical School, Cottingham, United Kingdom.ORCID 0000-0002-6135-9610
Lorcan P McGarveyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland.
Ian D PavordOxford National Institute for Health Research Respiratory Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; and.
Allison Martin NguyenMerck & Co., Inc., Rahway, New Jersey.ORCID 0000-0002-6385-5570
Jonathan SchelfhoutMerck & Co., Inc., Rahway, New Jersey.
Qing LiMerck & Co., Inc., Rahway, New Jersey.
Beata IskoldMerck & Co., Inc., Rahway, New Jersey.
Stuart A GreenMerck & Co., Inc., Rahway, New Jersey.
George PhilipMerck & Co., Inc., Rahway, New Jersey.ORCID 0000-0002-3906-7232
David R MuccinoMerck & Co., Inc., Rahway, New Jersey.
Carmen La RosaMerck & Co., Inc., Rahway, New Jersey.

Funding

Department of HealthWellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antitussive AgentsCoughBenzenesulfonamidesChronic DiseaseHumansPyrimidinesSulfonamidesAntitussive AgentsBenzenesulfonamidesGefapixantPyrimidinesSulfonamides

Identifiers

PMID36996347
PMCPMC10263136

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.