Evidence map›Paper›PMID 36996337›Full record

ArticleResearch (Washington, D.C.)2023

Reconfigurable Vortex-like Paramagnetic Nanoparticle Swarm with Upstream Motility and High Body-length Ratio Velocity.

Luyao Wang, Han Gao, Hongyan Sun, Yiming Ji, Li Song, Lina Jia, Chutian Wang, Chan Li, Deyuan Zhang, Ye Xu and 2 more

Open access · goldFull text read
In one paragraph

Article in Research (Washington, D.C.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 44 citations in OpenAlex.

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  13. Boundarics in Biomedicine.Research (Washington, D.C.) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Luyao WangSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Han GaoSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Hongyan SunSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Yiming JiSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Li SongSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Lina JiaSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Chutian WangSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Chan LiSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Deyuan ZhangSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Ye XuSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Huawei ChenSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Lin FengSchool of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China.
Beihang University · CNBeijing Advanced Sciences and Innovation Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug delivery systems with high-targeted doses can minimize excipients, reduce side effects, and improve efficacy. Human blood circulation is a complex circulatory system, and the motion control of microrobots in the static flow field in vitro is completely different from in vivo. How to achieve precise counterflow motion for targeted drug delivery without vascular blockage and immune rejection is the biggest challenge for micro-nano robots. Here, we propose a control method that enables vortex-like paramagnetic nanoparticle swarm (VPNS) to move upstream against the flow. By mimicking the clustering motion of wild herring schools and the rolling of leukocytes, VPNS are incredibly stable even when subjected to high-intensity jet impacts in the blood environment, can travel upstream, anchor at the target location, and dissipate when the magnetic field is withdrawn, which greatly reduces the risk of thrombosis. VPNS can also upstream along the vessel wall without an additional energy source and has a marked targeted therapeutic effect on subcutaneous tumors.

Identifiers

PMID36996337
PMCPMC10042322
OpenAlexW4321085913

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read58
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.