Evidence map›Paper›PMID 36996117›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

A DNA damage-induced phosphorylation circuit enhances Mec1

Luke A Yates, Elias A Tannous, R Marc Morgan, Peter M Burgers, Xiaodong Zhang

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Fission yeast RPA-TERT-Tpz1bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. DNA Damage and Replication Stress Checkpoints.Annual review of biochemistry · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Luke A YatesSection of Structural Biology, Department of Infectious Disease, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom.ORCID 0000-0002-5023-0803
Elias A TannousDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0001-8073-1599
R Marc MorganDepartment of Life Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom.ORCID 0000-0002-9760-3638
Peter M BurgersDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO 63110.
Xiaodong ZhangSection of Structural Biology, Department of Infectious Disease, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom.ORCID 0000-0001-9786-7038
Imperial College London · GBWashington University in St. Louis · US

Funding

MECHANISMS OF DNA REPLICATION AND MAINTENANCE IN EUKARYOTESR35GM118129 · NIGMS · WASHINGTON UNIVERSITY · PI BURGERS, PETER M · 2016 to 2025
$6.7M
NIGMS NIH HHS R35 GM118129Wellcome Trust 210658/Z/18/Z
6 · The paper itself

Abstract

The cell cycle checkpoint kinase Mec1

Indexed as

Replication Protein ASaccharomyces cerevisiae ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsDNA DamageDNA ReplicationIntracellular Signaling Peptides and ProteinsPhosphorylationProtein Serine-Threonine KinasesSaccharomyces cerevisiaeAdaptor Proteins, Signal TransducingCell Cycle ProteinsIntracellular Signaling Peptides and ProteinsLCD1 protein, S cerevisiaeMEC1 protein, S cerevisiaeProtein Serine-Threonine KinasesReplication Protein ASaccharomyces cerevisiae Proteinscheckpoint kinaseDNA damage signalingprotein phosphorylationreplication stressstructural biology

Identifiers

PMID36996117
PMCPMC10083555
OpenAlexW4361255903

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.