Evidence map›Paper›PMID 36996110›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine release revealed by a GRAB sensor.

Zhaofa Wu, Yuting Cui, Huan Wang, Hao Wu, Yi Wan, Bohan Li, Lei Wang, Sunlei Pan, Wanling Peng, Ao Dong and 5 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 74 citations in OpenAlex.

  1. ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  15. Adenosine in the Brain: Recent Progress on Detection, Function, and Translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  16. Astrocytic CaNature neuroscience · 2025
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Zhaofa WuState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0003-2027-5194
Yuting CuiNational Institute of Biological Sciences, Beijing 102206, China.
Huan WangState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-7472-0057
Hao WuSchool of Life Sciences, Tsinghua University, Beijing 100084, China.
Yi WanState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Bohan LiState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Lei WangState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Sunlei PanState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Wanling PengInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-9770-5001
Ao DongState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-2821-9528
Zhengwei YuanNational Institute of Biological Sciences, Beijing 102206, China.
Miao JingChinese Institute for Brain Research, Beijing 102206, China.ORCID 0000-0002-7782-5065
Min XuInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-6936-7543
Minmin LuoNational Institute of Biological Sciences, Beijing 102206, China.ORCID 0000-0003-3535-6624
Yulong LiState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-9166-9919
Peking University · CNChinese Academy of Sciences · CNNational Institute of Biological Sciences, Beijing · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNChinese Institute for Brain Research · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purinergic signaling molecule adenosine (Ado) modulates many physiological and pathological functions in the brain. However, the exact source of extracellular Ado remains controversial. Here, utilizing a newly optimized genetically encoded GPCR-Activation-Based Ado fluorescent sensor (GRAB

Indexed as

AdenosineNeuronsGuanine Nucleotide Exchange FactorsNucleoside Transport ProteinsSignal TransductionAdenosineGuanine Nucleotide Exchange FactorsNucleoside Transport ProteinsadenosineENT transporterneuronal activitysomatodendrite

Identifiers

PMID36996110
PMCPMC10083574
OpenAlexW4361255899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.