Evidence map›Paper›PMID 36995940›Full record

ArticleCell reports2023

Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self.

Kristina M Geiger, Michael Manoharan, Rachel Coombs, Kathya Arana, Chan-Su Park, Angus Y Lee, Nilabh Shastri, Ellen A Robey, Laurent Coscoy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. The murine MHC-E molecule Qa-1Frontiers in immunology · 2026
    Article
  4. Unconventional CD8Science advances · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Oncolytic α-herpesvirus and myeloid-tropic cytomegalovirus cooperatively enhance systemic antitumor responses.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristina M GeigerDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Michael ManoharanDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Rachel CoombsDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kathya AranaDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Chan-Su ParkDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Angus Y LeeCancer Research Lab, University of California, Berkeley, Berkeley, CA 94720, USA.
Nilabh ShastriDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ellen A RobeyDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: erobey@berkeley.edu.
Laurent CoscoyDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: lcoscoy@berkeley.edu.

Funding

Immunology & Pathogenesis Program Training GrantT32AI100829 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Gregory M Barton, ELLEN A ROBEY · 2012 to 2026
$4.7M
Presentation of Qa-1 restricted peptides during homeostasis and viral infectionR01AI149341 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI COSCOY, LAURENT, ROBEY, ELLEN A · 2020 to 2024
$2.9M
NIAID NIH HHS R01 AI149341NIAID NIH HHS T32 AI100829
6 · The paper itself

Abstract

The endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP) plays a crucial role in shaping the peptide-major histocompatibility complex (MHC) class I repertoire and maintaining immune surveillance. While murine cytomegalovirus (MCMV) has multiple strategies for manipulating the antigen processing pathway to evade immune responses, the host has also developed ways to counter viral immune evasion. In this study, we find that MCMV modulates ERAAP and induces an interferon γ (IFN-γ)-producing CD8

Indexed as

Antigen PresentationMuromegalovirusAminopeptidasesAnimalsCD8-Positive T-LymphocytesEndoplasmic ReticulumHistocompatibility Antigens Class ILeucyl AminopeptidaseMiceMinor Histocompatibility AntigensPeptidesAminopeptidasesERAP1 protein, mouseHistocompatibility Antigens Class ILeucyl AminopeptidaseMinor Histocompatibility AntigensPeptidesanti-viralCP: ImmunologyERAAPimmune evasionimmune surveillancemurine cytomegalovirusnon-classical Qa-1bQFL T cellsunconventional

Identifiers

PMID36995940
PMCPMC10539480

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.