ArticleArquivos brasileiros de oftalmologia2023
Botulinum toxin A for the treatment of strabismus in children with neurological impairment.
Article in Arquivos brasileiros de oftalmologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Long-Term Outcomes of Strabismus Surgery in Children with Cerebral Palsy: Focus on Consecutive Exotropia.Children (Basel, Switzerland) · 2026Article
- Non-surgical treatment of strabismus in children: a review of recent advances.Frontiers in medicine · 2025Review
- Dose-Effect Relationship of Botulinum Toxin Type A in the Management of Strabismus: A Review.Cureus · 2024Review
- Golden Indications and an Overview on the Use of Botulinum Toxin in Strabismus.Turkish journal of ophthalmology · 2023Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposesTo assess the efficacy of botulinum toxin A injection in the treatment of strabismus in patients with neurological impairment and evaluate the factors associated with treatment success.
methodsThe study included 50 patients with strabismus and neurological impairment. In all children, botulinum toxin injection was performed into the appropriate extraocular muscle. The relationship between demographic features, clinical characteristics, and treatment success were analyzed.
resultsIn the study group, 34 patients had esotropia, and 16 patients had exotropia. As neurological problems, 36 patients had cerebral palsy, and 14 had hydrocephalus. The average follow-up period was 15.3 ± 7.3 months. The mean number of injections was 1.4 ± 0.6. The mean angle of deviation was 42.5 ± 13.2 PD before the treatment, which decreased to 12.8 ± 11.9 PD after the treatment. Successful motor alignment (orthotropia within 10 PD) was achieved in 60% of the patients. Binary logistic regression analysis revealed that esotropic misalignment and shorter duration of strabismus was significantly associated with treatment success in the study group. Patients with esotropia and lower angles of misalignment were more likely to be treated with a single injection.
conclusionThe use of botulinum toxin A for the treatment of strabismus in children with neurological impairment is a good alternative to conventional surgical therapy with a lower risk of overcorrection. The treatment outcome is better in esodeviations and shorter duration of strabismus, implying an advantage of early treatment.
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