Evidence map›Paper›PMID 36995657›Full record

ArticleApplied biochemistry and biotechnology2023

Organosulfur Compound Identified from Striga angustifolia (D. Don) C.J. Saldanha Inhibits Lung Cancer Growth and Induces Apoptosis via p53/mTOR Signaling Pathway.

Kannan Raja, Arumugam Vignesh, Ponnusamy Lavanya, Manoharan Ravi, Subramaniam Selvakumar, Krishnan Vasanth

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Article in Applied biochemistry and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kannan RajaDepartment of Botany, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India.
Arumugam VigneshDepartment of Botany, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India.
Ponnusamy LavanyaDepartment of Biochemistry, Guindy Campus, University of Madras, Chennai, 600025, India.
Manoharan RaviDepartment of Biochemistry, Guindy Campus, University of Madras, Chennai, 600025, India.
Subramaniam SelvakumarDepartment of Biochemistry, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India.
Krishnan VasanthDepartment of Botany, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India. vasanthlabbu@gmail.com.ORCID http://orcid.org/0000-0002-9091-1523
Bharathiar University · INUniversity of Madras · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Striga angustifolia (D. Don) C.J. Saldanha was used as an Ayurvedic and homeopathic medicine for cancer by the tribal peoples of the Maruthamalai Hills, Coimbatore, India. Hence, the traditional use that has been proven to be effective lacks convincing scientific references. This present study was conducted to investigate the presence of potentially bioactive compounds from S. angustifolia and provides a scientific basis for the ethnobotanical utility. The organosulfur compound 5,5'-dithiobis(1-phenyl-1H-tetrazole) (COMP1) was isolated from S. angustifolia extracts, and the structures of COMP1 were elucidated and characterized by using

Indexed as

Lung NeoplasmsStrigaApoptosisCell Line, TumorCell ProliferationHumansSignal TransductionTOR Serine-Threonine KinasesTumor Suppressor Protein p53TOR Serine-Threonine KinasesTumor Suppressor Protein p535,5′-Dithiobis(1-phenyl-1H-tetrazole)AnticancerApoptosisNatural productp53 pathwayStriga angustifolia

Identifiers

PMID36995657
OpenAlexW4361274181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.