Evidence map›Paper›PMID 36995508›Full record

ReviewMaxillofacial plastic and reconstructive surgery2023

Nanomedicine and nanoparticle-based delivery systems in plastic and reconstructive surgery.

Jea Giezl N Solidum, Jeremy A Ceriales, Erika P Ong, Eric David B Ornos, Ruth Joy L Relador, Elgin Paul B Quebral, Jose Florencio F Lapeña, Ourlad Alzeus G Tantengco, Ka Yiu Lee

Abstract readReview
In one paragraph

Review in Maxillofacial plastic and reconstructive surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jea Giezl N SolidumMD-PhD (Molecular Medicine) Program, College of Medicine, University of the Philippines Manila, Ermita, Manila, 1000, Philippines.
Jeremy A CerialesMD-PhD (Molecular Medicine) Program, College of Medicine, University of the Philippines Manila, Ermita, Manila, 1000, Philippines.
Erika P OngCollege of Medicine, University of the Philippines Manila, Ermita, Manila, 1000, Philippines.
Eric David B OrnosMD-PhD (Molecular Medicine) Program, College of Medicine, University of the Philippines Manila, Ermita, Manila, 1000, Philippines.
Ruth Joy L ReladorMD-PhD (Molecular Medicine) Program, College of Medicine, University of the Philippines Manila, Ermita, Manila, 1000, Philippines.
Elgin Paul B QuebralMD-PhD (Molecular Medicine) Program, College of Medicine, University of the Philippines Manila, Ermita, Manila, 1000, Philippines.
Jose Florencio F LapeñaDepartment of Otolaryngology - Head and Neck Surgery, Section of Craniomaxillofacial Plastic and Restorative Surgery, College of Medicine - Philippine General Hospital, University of the Philippines Manila, Ermita, Manila, 1000, Philippines.
Ourlad Alzeus G TantengcoDepartment of Physiology, College of Medicine, University of the Philippines Manila, Ermita, Manila, 1000, Philippines. ogtantengco@up.edu.ph.
Ka Yiu LeeSwedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden. kyle.lee@miun.se.ORCID http://orcid.org/0000-0001-5577-0940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNanotechnology and nanomedicine are rising novel fields in plastic and reconstructive surgery (PRS). The use of nanomaterials often goes with regenerative medicine. Due to their nanoscale, these materials stimulate repair at the cellular and molecular levels. Nanomaterials may be placed as components of nanocomposite polymers allowing enhancement of overall biochemical and biomechanical properties with improved scaffold properties, cellular attachment, and tissue regeneration. They may also be formulated as nanoparticle-based delivery systems for controlled release of signal factors or antimicrobials, for example. However, more studies on nanoparticle-based delivery systems still need to be done in this field. Nanomaterials are also used as frameworks for nerves, tendons, and other soft tissues. MAIN BODY: In this mini-review, we focus on nanoparticle-based delivery systems and nanoparticles targeting cells for response and regeneration in PRS. Specifically, we investigate their roles in various tissue regeneration, skin and wound healing, and infection control. Cell surface-targeted, controlled-release, and inorganic nanoparticle formulations with inherent biological properties have enabled enhanced wound healing, tumor visualization/imaging, tissue viability, and decreased infection, and graft/transplantation rejection through immunosuppression.

conclusionsNanomedicine is also now being applied with electronics, theranostics, and advanced bioengineering technologies. Overall, it is a promising field that can improve patient clinical outcomes in PRS.

Indexed as

Delivery systemsNanomedicineNanotechnologyPlastic surgeryReconstructive surgeryRegenerative medicine

Identifiers

PMID36995508
PMCPMC10060935

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.