ArticleeLife2023
Model-based whole-brain perturbational landscape of neurodegenerative diseases.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 46 citations in OpenAlex.
- An Augmented Reality-Based Concept for Anchor-Free Assessment of Tremor-Related Hand Movement Patterns.Journal of imaging · 2026Article
- Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.PLoS computational biology · 2026Article
- The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus.BMC medicine · 2026Article
- A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.Nature aging · 2026Article
- A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Excitation-inhibition homeostasis in Alzheimer's disease: a selective multiscale review of mechanisms, sex differences, and therapeutic opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Advanced neuroimaging assessment of neurodegenerative dementia syndromes: A framework for comprehensive multimodal FDG-PET, MR-perfusion, and MR-diffusion analysis.NeuroImage. Clinical · 2026Article
- Perturbations of whole-brain model reveal critical areas related to relapse of early psychosis.Network neuroscience (Cambridge, Mass.) · 2026Article
- Optimal stochastic tracking control for brain network dynamics.Communications biology · 2025Article
- Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Creative experiences and brain clocks.Nature communications · 2025Article
- Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.Nature. Mental health · 2025Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.bioRxiv : the preprint server for biology · 2025Article
- Local homeostasis preserves global neural dynamics compensating for structural loss during human lifespan aging.Communications biology · 2025Article
- Beyond Focal Lesions: Dynamical Network Effects of White Matter Hyperintensities.Human brain mapping · 2024Article
- The Algorithmic Agent Perspective and Computational Neuropsychiatry: From Etiology to Advanced Therapy in Major Depressive Disorder.Entropy (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 10 countries.
Funding
Abstract
The treatment of neurodegenerative diseases is hindered by lack of interventions capable of steering multimodal whole-brain dynamics towards patterns indicative of preserved brain health. To address this problem, we combined deep learning with a model capable of reproducing whole-brain functional connectivity in patients diagnosed with Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD). These models included disease-specific atrophy maps as priors to modulate local parameters, revealing increased stability of hippocampal and insular dynamics as signatures of brain atrophy in AD and bvFTD, respectively. Using variational autoencoders, we visualized different pathologies and their severity as the evolution of trajectories in a low-dimensional latent space. Finally, we perturbed the model to reveal key AD- and bvFTD-specific regions to induce transitions from pathological to healthy brain states. Overall, we obtained novel insights on disease progression and control by means of external stimulation, while identifying dynamical mechanisms that underlie functional alterations in neurodegeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.