ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Optimally Configured Optical Fiber Near-Field Enhanced Plasmonic Resonance Immunoprobe for the Detection of Alpha-Fetoprotein.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Overview of Optical Fiber Biosensors for the Detection of Cancer Biomarkers in the Past Decade.ACS omega · 2026Review
- Deterministic Fabrication of Plasmonic Nanostructures on Optical Nanofibers via Blurred Electron Beam Deposition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Study on vibration characteristics of the dike crossing pipeline based on EWT and CWT.Heliyon · 2024Article
- Optimally Configured Optical Fiber Near-Field Enhanced Plasmonic Resonance Immunoprobe for the Detection of Alpha-Fetoprotein.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
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Authors and funding
7 authors.
Funding
Abstract
The detection of trace biomarkers is an important supplementary approach for early screening and diagnoses of tumors. An optical fiber near-field enhanced plasmonic resonance immunoprobe is developed for the detection of the hepatocellular carcinoma biomarker, i.e., the alpha-fetoprotein. Generic principles based on dispersion models and finite element analysis (FEA) models are developed to realize the optimized configuration of spectral characteristics of the immunoprobe. Dispersion models provide theoretical guidance for the design of the multilayer sensing structure from the perspective of the ray optics theory. FEA models provide theoretical guidance for the selection of coating materials from the perspective of the self-defined dielectric constant ratio, i.e., the ratio of the real part to the imaginary part. The optimized configuration of the antibody coupling further improves the biosensing performance of the immunoprobe. The limit of detection (LOD) can reach down to 0.01 ng mL
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