Evidence map›Paper›PMID 36994866›Full record

ReviewThe Journal of international medical research2023

Insulin resistance and cardiovascular disease.

Constantine E Kosmas, Maria D Bousvarou, Christina E Kostara, Evangelia J Papakonstantinou, Evdokia Salamou, Eliscer Guzman

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of international medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed, 11 pooled it
66.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

227 citing papers in PubMed, 11 syntheses or guidelines pooled it, 311 citations in OpenAlex.

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167 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Constantine E KosmasDivision of Cardiology, Department of Medicine, Montefiore Medical Center, Bronx, NY, USA.ORCID 0000-0003-3926-0304
Maria D BousvarouSchool of Medicine, University of Crete, Heraklion, Greece.
Christina E KostaraLaboratory of Clinical Chemistry, Medical Department, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece.ORCID 0000-0001-7045-1323
Evangelia J PapakonstantinouGeneral Directorate of Public Health and Social Welfare, Attica Region, Athens, Greece.
Evdokia SalamouAthens Bioclinic, Athens, Greece.
Eliscer GuzmanDivision of Cardiology, Department of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Montefiore Medical Center · USUniversity of Crete · GRUniversity of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public health hazards, especially in today's Western societies. A causal-effect relationship has been established that links IR with CVD. The mediating mechanisms are perplexing, under ongoing, rigorous investigation and remain to be fully elucidated. IR is a condition encompassing hyperglycemia and compensatory hyperinsulinemia. It occurs when insulin is not capable of exerting its maximum effects on target tissues, including skeletal muscles, liver and adipose tissue. This alteration of insulin signaling pathways results in the development of cardiometabolic disorders, including obesity, dyslipidemia, low-grade inflammation, endothelial dysfunction and hypertension, all of which are predisposing factors for atherosclerosis and CVD. The management of IR can be achieved through dietary modifications, the inclusion of regular exercise routines in everyday life, pharmacological agents and other interventions tailored to each individual patient's needs. It is important to underline though that, although various antidiabetic drugs that may improve IR are available, no medications are as yet specifically approved for the treatment of IR. This narrative review will focus on the current scientific and clinical evidence pertaining to IR, the mechanisms connecting IR with CVD, as well as plausible strategies for a holistic, personalized approach for IR management.

Indexed as

Cardiovascular DiseasesHypertensionInsulin ResistanceHumansInsulinObesityInsulincardiovascular diseasedyslipidemiaendothelial dysfunctionhypertensioninflammationInsulininsulin resistanceoxidative stress

Identifiers

PMID36994866
PMCPMC10069006
OpenAlexW4361273400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.