Evidence map›Paper›PMID 36994857›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

A pilot study of lymphoscintigraphy with tracer injection into the human brain.

Andrew T Coxon, Rupen Desai, Pujan R Patel, Ananth K Vellimana, Jon T Willie, Joshua L Dowling, Eric C Leuthardt, Albert H Kim, Tanner M Johanns, Barry A Siegel and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. The glymphatic system and glioblastoma.Brain : a journal of neurology · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Andrew T CoxonWashington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9632-0871
Rupen DesaiDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Pujan R PatelWashington University School of Medicine, St. Louis, MO, USA.
Ananth K VellimanaDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Jon T WillieDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Joshua L DowlingDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Eric C LeuthardtDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Albert H KimDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Tanner M JohannsAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Barry A SiegelAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Gavin P DunnDepartment of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Washington University in St. Louis · USNeurological Surgery · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Washington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7M
Washington University Institute of Clinical and Translational Sciences (TL1)TL1TR002344 · NCATS · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2017 to 2026
$8.5M
NCATS NIH HHS TL1 TR002344NCI NIH HHS K12 CA167540NCI NIH HHS P30 CA091842
6 · The paper itself

Abstract

Many groups have reported lymphatic and glymphatic structures in animal and human brains, but tracer injection into the human brain to demonstrate real-time lymphatic drainage and mapping has not been described. We enrolled patients undergoing standard-of-care resection or stereotactic biopsy for suspected intracranial tumors. Patients received peritumoral injections of

Indexed as

LymphoscintigraphySentinel Lymph Node BiopsyDextransHumansLymphatic MetastasisMannansPilot ProjectsRadiopharmaceuticalsTechnetium Tc 99m PentetateDextransMannansRadiopharmaceuticalstechnetium-diethylenetriaminepentaacetic acid-mannosyl-dextranTechnetium Tc 99m PentetateBrainglymphaticslymphaticsneuroimmunologytilmanocept

Identifiers

PMID36994857
PMCPMC10369147
OpenAlexW4361273481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.