ArticlePediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Tissue Shrinkage of Resected Specimens in Hirschsprung's Disease: Why Pediatric Surgeons Think the Bowel Specimen was Longer Than Indicated in the Pathology Report.
Article in Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Distal resection margins before and after fixation: a comparative analysis in rectal cancer surgery.Frontiers in surgery · 2026Article
- Evaluation of an Ipsilateral Uterine Horn Resection and Ovariectomy Surgical Model in Gilts for Embryo Collection.Animals : an open access journal from MDPI · 2025Article
- Anti-Shrinkage Technique for Feline Skin Samples.Veterinary sciences · 2024Article
- Surgery for intestinal injuries in very preterm infants: a Norwegian population-based study with a new approach to disease classification.BMJ paediatrics open · 2024Article
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7 authors.
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Abstract
backgroundHirschsprung disease (HD) is an aganglionosis of variable length starting at the rectosigmoid colon with surgery as sole therapeutic option. The length of the resected bowel segment is a crucial information for the treating surgeons and influences the prognosis of the patient. It is often artificially altered due to post operative tissue shrinkage. The objective of this study is to quantify the extent tissue shrinkage of HD specimens. MATERIAL AND
methodsColorectal HD specimens were measured at the time of surgery and at the time of cut-up, either fresh or after formalin fixation and statistically analyzed.
resultsSixteen colorectal specimens were included. Following formalin fixation the specimen length decreased by 22.7% (
conclusionThis study showed that there is significant tissue shrinkage in HD specimens. The 2 different cohorts revealed that tissue shrinkage is mostly caused by tissue retraction/alteration after organ removal but also to a lesser extent by fixation with formalin. Surgeons and (neuro-)pathologists should be aware of the sizeable shrinking artifact to avoid unnecessary confusion.
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