ArticlePlant physiology2023
The trans-zeatin-type side-chain modification of cytokinins controls rice growth.
Article in Plant physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Cultivar-dependent regulation of cytokinin biosynthesis in wheat: developmental expression of TaIPT genes and hormonal crosstalk during reproductive development.BMC plant biology · 2026Article
- Phytohormone and transcriptome analyses unravel the molecular mechanisms of heterophylly in Pinellia ternata.BMC plant biology · 2026Article
- Five unaddressed questions about cytokinin biosynthesis.Journal of experimental botany · 2025Review
- Transcriptome Profiling Reveals the Effects of Rootstocks on Scion Architecture inPlants (Basel, Switzerland) · 2025Article
- The cytokinin efflux transporter ABCC4 participates in Arabidopsis root system development.Plant physiology · 2024Article
- Multi-omics signatures of diverse plant callus cultures.Plant biotechnology (Tokyo, Japan) · 2024Article
- Spatially distributed cytokinins: Metabolism, signaling, and transport.Plant communications · 2024Review
- Cytokinin: From autoclaved DNA to two-component signaling.The Plant cell · 2024Review
- Dynamic changes of endogenous phytohormones and carbohydrates during spontaneous morphogenesis ofFrontiers in plant science · 2024Article
- Cytokinin Translocation to, and Biosynthesis and Metabolism within, Cereal and Legume Seeds: Looking Back to Inform the Future.Metabolites · 2023Review
- A cell wall-localized cytokinin/purine riboside nucleosidase is involved in apoplastic cytokinin metabolism inProceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinins (CKs), a class of phytohormones with vital roles in growth and development, occur naturally with various side-chain structures, including N6-(Δ2-isopentenyl)adenine-, cis-zeatin- and trans-zeatin (tZ)-types. Recent studies in the model dicot plant Arabidopsis (Arabidopsis thaliana) have demonstrated that tZ-type CKs are biosynthesized via cytochrome P450 monooxygenase (P450) CYP735A and have a specific function in shoot growth promotion. Although the function of some of these CKs has been demonstrated in a few dicotyledonous plant species, the importance of these variations and their biosynthetic mechanism and function in monocots and in plants with distinctive side-chain profiles other than Arabidopsis, such as rice (Oryza sativa), remain elusive. In this study, we characterized CYP735A3 and CYP735A4 to investigate the role of tZ-type CKs in rice. Complementation test of the Arabidopsis CYP735A-deficient mutant and CK profiling of loss-of-function rice mutant cyp735a3 cyp735a4 demonstrated that CYP735A3 and CYP735A4 encode P450s required for tZ-type side-chain modification in rice. CYP735As are expressed in both roots and shoots. The cyp735a3 cyp735a4 mutants exhibited growth retardation concomitant with reduction in CK activity in both roots and shoots, indicating that tZ-type CKs function in growth promotion of both organs. Expression analysis revealed that tZ-type CK biosynthesis is negatively regulated by auxin, abscisic acid, and CK and positively by dual nitrogen nutrient signals, namely glutamine-related and nitrate-specific signals. These results suggest that tZ-type CKs control the growth of both roots and shoots in response to internal and environmental cues in rice.
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