Evidence map›Paper›PMID 36994768›Full record

ReviewComprehensive Physiology2023

Autonomic Cardiovascular Control in Health and Disease.

Shahid Karim, Anwar Chahal, Mohammed Y Khanji, Steffen E Petersen, Virend K Somers

Abstract readReview
In one paragraph

Review in Comprehensive Physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  5. Neurovascular interactions in the ageing heart.Nature reviews. Cardiology · 2026
    Review
  6. Article
  7. Article
  8. The bidirectional mechanistic links between Alzheimer's disease and cardiovascular disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Comparative analysis of autonomic effects of ketamine-xylazine in normotensive and hypertensive rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shahid KarimMayo Clinic, Rochester, Minnesota, USA.
Anwar ChahalMayo Clinic, Rochester, Minnesota, USA.
Mohammed Y KhanjiWilliam Harvey Research Institute, NIHR Barts Biomedical Centre, Queen Mary University, London, UK.
Steffen E PetersenWilliam Harvey Research Institute, NIHR Barts Biomedical Centre, Queen Mary University, London, UK.
Virend K SomersMayo Clinic, Rochester, Minnesota, USA.

Funding

Sleep Apnea and Hypertrophic Cardiomyopathy - Implications for Arrhythmia and Sudden DeathR01HL134885 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 2017 to 2020
$3.0M
NHLBI NIH HHS R01 HL134885
6 · The paper itself

Abstract

Autonomic neural control of the cardiovascular system is formed of complex and dynamic processes able to adjust rapidly to mitigate perturbations in hemodynamics and maintain homeostasis. Alterations in autonomic control feature in the development or progression of a multitude of diseases with wide-ranging physiological implications given the neural system's responsibility for controlling inotropy, chronotropy, lusitropy, and dromotropy. Imbalances in sympathetic and parasympathetic neural control are also implicated in the development of arrhythmia in several cardiovascular conditions sparking interest in autonomic modulation as a form of treatment. A number of measures of autonomic function have shown prognostic significance in health and in pathological states and have undergone varying degrees of refinement, yet adoption into clinical practice remains extremely limited. The focus of this contemporary narrative review is to summarize the anatomy, physiology, and pathophysiology of the cardiovascular autonomic nervous system and describe the merits and shortfalls of testing modalities available. © 2023 American Physiological Society. Compr Physiol 13:4493-4511, 2023.

Indexed as

Cardiovascular DiseasesCardiovascular SystemArrhythmias, CardiacAutonomic Nervous SystemHeartHumans

Identifiers

PMID36994768
PMCPMC10406398

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.