ArticleThe EMBO journal2023
Blood endothelial ALK1-BMP4 signaling axis regulates adult hair follicle stem cell activation.
Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 11 citations in OpenAlex.
- H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers.Nature communications · 2026Article
- Article
- HmmrResearch (Washington, D.C.) · 2026Article
- Vascular endothelial cells as signaling niches for epithelial stem cells in the skin.Frontiers in cell and developmental biology · 2026Review
- The Skin Microenvironment: A Dynamic Regulator of Hair Follicle Development, Cycling and Disease.Biomolecules · 2025Review
- Cholesterol promotes hair growth through activating sympathetic nerves and enhancing the proliferation of hair follicle stem cells.Molecular medicine (Cambridge, Mass.) · 2025Article
- BMP4 regulates differentiation of nestin-positive stem cells into melanocytes.Cellular and molecular life sciences : CMLS · 2025Article
- THSD4 promotes hair growth by facilitating dermal papilla and hair matrix interactions.Theranostics · 2025Article
- Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis.Cells & development · 2024Article
- Local and systemic mechanisms that control the hair follicle stem cell niche.Nature reviews. Molecular cell biology · 2024Review
- Translational frontiers: insight from lymphatics in skin regeneration.Frontiers in physiology · 2024Review
- Alk1 acts in non-endothelial VE-cadherinNature communications · 2023Article
- Blood endothelial ALK1-BMP4 signaling axis regulates adult hair follicle stem cell activation.The EMBO journal · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Blood vessels can play dual roles in tissue growth by transporting gases and nutrients and by regulating tissue stem cell activity via signaling. Correlative evidence implicates skin endothelial cells (ECs) as signaling niches of hair follicle stem cells (HFSCs), but functional demonstration from gene depletion of signaling molecules in ECs is missing to date. Here, we show that depletion of the vasculature-factor Alk1 increases BMP4 secretion from ECs, which delays HFSC activation. Furthermore, while previous evidence suggests a lymphatic vessel role in adult HFSC activation possibly through tissue drainage, a blood vessel role has not yet been addressed. Genetic perturbation of the ALK1-BMP4 axis in all ECs or the lymphatic ECs specifically unveils inhibition of HFSC activation by blood vessels. Our work suggests a broader relevance of blood vessels, adding adult HFSCs to the EC functional repertoire as signaling niches for the adult stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.