Evidence map›Paper›PMID 36994536›Full record

ArticleZoological research2023

Cell atlas of CCl

Peng-Cheng Guo, Jing Zuo, Ke-Ke Huang, Guang-Yao Lai, Xiao Zhang, Juan An, Jin-Xiu Li, Li Li, Liang Wu, Yi-Ting Lin and 22 more

Open access · diamondAbstract read
In one paragraph

Article in Zoological research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. p21Nature aging · 2026
    Article
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 7 institutions in 3 countries.

Peng-Cheng GuoState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China.
Jing ZuoBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Ke-Ke HuangKey Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510799, China.
Guang-Yao LaiBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Xiao ZhangState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China.
Juan AnBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Jin-Xiu LiBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Li LiLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.
Liang WuLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.
Yi-Ting LinLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.
Dong-Ye WangLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.
Jiang-Shan XuBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Shi-Jie HaoBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Yang WangBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Rong-Hai LiBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Wen MaBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Yu-Mo SongBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Chang LiuBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Chuan-Yu LiuBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Zhen DaiGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.
Yan XuBiotherapy Centre, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Amar Deep SharmaDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.
Michael OttDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.
Qing Ou-YangDepartment of Hepatobiliary Surgery and Liver Transplant Center, General Hospital of Southern Theater Command, Guangzhou, Guangdong 510010, China.
Feng HuoDepartment of Hepatobiliary Surgery and Liver Transplant Center, General Hospital of Southern Theater Command, Guangzhou, Guangdong 510010, China.
Rong FanDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, Guangdong 510515, China.
Yong-Yin LiDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, Guangdong 510515, China.
Jin-Lin HouDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, Guangdong 510515, China.
Giacomo VolpeHematology and Cell Therapy Unit, IRCCS-Istituto Tumori 'Giovanni Paolo II', Bari 70124, Italy.
Long-Qi LiuBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
Miguel A EstebanState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China.
Yi-Wei LaiBGI-Hangzhou, Hangzhou, Zhejiang 310012, China.
BGI Group (China) · CNGuangzhou Institutes of Biomedicine and Health · CNGeneral Hospital of Guangzhou Military Command · CNMedizinische Hochschule Hannover · DESouthern Medical University · CNSun Yat-sen University · CNIstituto Tumori Bari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis, a major cause of morbidity and mortality worldwide. However, there are currently no effective anti-fibrotic therapies available, especially for late-stage patients, which is partly attributed to the major knowledge gap regarding liver cell heterogeneity and cell-specific responses in different fibrosis stages. To reveal the multicellular networks regulating mammalian liver fibrosis from mild to severe phenotypes, we generated a single-nucleus transcriptomic atlas encompassing 49 919 nuclei corresponding to all main liver cell types at different stages of murine carbon tetrachloride (CCl

Indexed as

Endothelial CellsLiver CirrhosisAnimalsCarbon TetrachlorideCell CommunicationMammalsMiceCarbon TetrachlorideAngiogenesisCell-cell interactionsGene regulatory networksHepatic stellate cellsHepatocytesLiver fibrosisSingle-cell and single-nucleus RNA-sequencingToxicity

Identifiers

PMID36994536
PMCPMC10236302
OpenAlexW4323892963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.