Evidence map›Paper›PMID 36994450›Full record

ArticleAnalytical cellular pathology (Amsterdam)2023

Suppression of lncRNA OIP5-AS1 Attenuates Apoptosis and Inflammation, and Promotes Proliferation by Mediating miR-25-3p Expression in Lipopolysaccharide-Induced Myocardial Injury.

Jiaju Ma, Hebu Qian, Han Zou

RetractedOpen access · goldFull text readRetracted Publication
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jiaju MaIntensive Care Unit, Suzhou Ninth People's Hospital, No. 2666, Ludang Road, Taihu New Town, Wujiang District, Suzhou, Jiangsu 215200, China.
Hebu QianIntensive Care Unit, Suzhou Ninth People's Hospital, No. 2666, Ludang Road, Taihu New Town, Wujiang District, Suzhou, Jiangsu 215200, China.
Han ZouIntensive Care Unit, Suzhou Ninth People's Hospital, No. 2666, Ludang Road, Taihu New Town, Wujiang District, Suzhou, Jiangsu 215200, China.ORCID https://orcid.org/0000-0002-0067-0632
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Long non-coding RNAs (LncRNAs) OIP5-AS1 and miR-25-3p play important roles in myocardial injury, whereas their roles in lipopolysaccharide (LPS)-induced myocardial injury remain unknown. The purpose of our study was to investigate the functional mechanisms of OIP5-AS1 and miR-25-3p in LPS-induced myocardial injury. Methods: Rats and H9C2 cells were treated with LPS to establish the model of myocardial injury Results: OIP5-AS1 was up-regulated, and miR-25-3p was down-regulated in myocardial tissues of LPS-induced rats and LPS-treated H9C2 cells. Knockdown of OIP5-AS1 relieved the myocardial injury in LPS-induced rats. Knockdown of OIP5-AS1 also inhibited the inflammation and apoptosis of myocardial cells Conclusion: Silencing of lncRNA OIP5-AS1 alleviated LPS-induced myocardial injury by regulating miR-25-3p.

Indexed as

MicroRNAsRNA, Long NoncodingAnimalsApoptosisCell ProliferationInflammationLipopolysaccharidesNF-kappa BRatsLipopolysaccharidesMicroRNAsMIRN25 microRNA, ratNF-kappa BRNA, Long Noncoding

Identifiers

PMID36994450
PMCPMC10042636
OpenAlexW4327942859

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read20
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.